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2.A.7.20.2
Crt homologue 1 (Chloroquine resistance transporter paralogue 1) (DdCRTp1)

Accession Number:Q9GSB0
Protein Name:Crt homologue 1
Length:473
Molecular Weight:51809.00
Species:Dictyostelium discoideum (Slime mold) [44689]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle membrane1 / Multi-pass membrane protein2
Substrate chloroquine

Cross database links:

eggNOG: NOG84011
Entrez Gene ID: 8620828   
Pfam: PF08627    PF03151   
KEGG: ddi:DDB_G027694   

Gene Ontology

GO:0030659 C:cytoplasmic vesicle membrane
GO:0016021 C:integral to membrane
GO:0012506 C:vesicle membrane

References (5)

[1] “Evidence for different mechanisms of chloroquine resistance in 2 Plasmodium species that cause human malaria.”  Nomura T.et.al.   11343215
[2] “Sequence and analysis of chromosome 2 of Dictyostelium discoideum.”  Gloeckner G.et.al.   12097910
[3] “The genome of the social amoeba Dictyostelium discoideum.”  Eichinger L.et.al.   15875012
[4] “Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT.”  Naude B.et.al.   15883156
[5] “Expression and function of pvcrt-o, a Plasmodium vivax ortholog of pfcrt, in Plasmodium falciparum and Dictyostelium discoideum.”  Sa J.M.et.al.   16987557

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTNNDKEKQP LLSSINNEDD NGATINIVEP VPWYSNIPQK IKNSMSKETI TILIYVVLYV 
61:	TSGVINSVLL KKVMNKFTNY AFFLSQLTNF GYVPIFGAVT AYKIFFTKDI PQETRDFPTR 
121:	KFAIMGALDA ITGFFVVIGG VSTSGPLQQL LNQAIIPFTM IASFIFLKER YSLIQLGGAL 
181:	VIIGGVVTSL IPSLLGGSSG GNKPFWNFFY LLSVIPGALS NVYKDIGFQA VADMDVWYLQ 
241:	YWDSLYQSIF GLFLFPVNNW LPPPATVKFE QILPFMKEGA ECLAGINSII PSYINGTSSF 
301:	TATSCTYAPD ATITCDDCHN AWIVIILYMT INIIYNIFIL LVLKHAGATV YSIANTLRLP 
361:	LTNIVFSIHF IMGSAVSPFS GLSVAGLVII LVGLGGYRVG SMIKQKKAAA AGGAIKVIPS 
421:	YGPAGMDNII PVQKEYIEPK SQAHLRNQFF GKLGINVPEA RYRAANNNNY GDA