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2.A.7.24.1
The mitochondrial thiamine-repressible putative thiamine pyrophosphate (TPP) transporter, Thi74 (370 aas; 10 TMSs in a 2 + 8 arrangement) (Mojzita and Hohmann, 2006)

Accession Number:Q04083
Protein Name:Thi74
Length:370
Molecular Weight:41385.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Mitochondrion membrane1 / Multi-pass membrane protein2
Substrate TPP

Cross database links:

Genevestigator: Q04083
eggNOG: fuNOG04138
HEGENOM: HBG396812
DIP: DIP-5126N
RefSeq: NP_010726.1   
Entrez Gene ID: 852048   
Pfam: PF00892   
KEGG: sce:YDR438W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0031966 C:mitochondrial membrane

References (4)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.”  Jacq C.et.al.   9169867
[2] “Topology models for 37 Saccharomyces cerevisiae membrane proteins based on C-terminal reporter fusions and predictions.”  Kim H.et.al.   12524434
[3] “Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae.”  Mojzita D.et.al.   16850348
[4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNRVGIDVDH MIGVLLLAVV VVFWVGASCL TNELLETNAY NKPFFLTYLN ISSFALYLTP 
61:	DLWRIIQSRR KSLQERTERT LPIHTQESFS EFLPLLSSTP STSSNLSSIA DTKVKDTMRL 
121:	SLLFCVLWFV ANLAANAALS YTTVASSTIL SSTSSFFTLF LATSLGIETF STKKLLGLFV 
181:	SLFGIILIVM QSSKQQDSVS ASSFLVGNTL ALLGSLGYSV YTTLLKYEIS SKGLRLDIQM 
241:	FLGYVGIFTF LLFWPILIIL DITHMETFEL PSNFHISFLV MLNCIIIFVS DYFWCKALIL 
301:	TSPLVVTVAL TFTIPLAMFA DFVWREAFFT PWYIIGVIFI FVSFFLVNHR GESAVEKDCA 
361:	AVEKGPILDA