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2.A.7.24.8
The thiamin uptake transporter, SLC35F3. Involved in hypertension.

Accession Number:Q8IY50
Protein Name:Solute carrier family 35 member F3
Length:421
Molecular Weight:46817.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate thiamin

Cross database links:

HOG000060188
Genevestigator: Q8IY50 Q8IY50
eggNOG: prNOG06464 NOG264574
Entrez Gene ID: 148641   
Pfam: PF00892   
KEGG: hsa:148641    hsa:148641   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0006810 P:transport

References (6)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKKHSARVAP LSACNSPVLT LTKVEGEERP RDSPGPAEAQ APAGVEAGGR ASRRCWTCSR 
61:	AQLKKIFWGV AVVLCVCSSW AGSTQLAKLT FRKFDAPFTL TWFATNWNFL FFPLYYVGHV 
121:	CKSTEKQSVK QRYRECCRFF GDNGLTLKVF FTKAAPFGVL WTLTNYLYLH AIKKINTTDV 
181:	SVLFCCNKAF VFLLSWIVLR DRFMGVRIVA AILAIAGIVM MTYADGFHSH SVIGIALVVA 
241:	SASMSALYKV LFKLLLGSAK FGEAALFLSI LGVFNILFIT CIPIILYFTK VEYWSSFDDI 
301:	PWGNLCGFSV LLLTFNIVLN FGIAVTYPTL MSLGIVLSIP VNAVIDHYTS QIVFNGVRVI 
361:	AIIIIGLGFL LLLLPEEWDV WLIKLLTRLK VRKKEEPAEG AADLSSGPQS KNRRARPSFA 
421:	R