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2.A.7.25.2
The nonimprinted in Prader-Willi/Angelman syndrom, subtype 2, NIPA2 protein (360 aas; 9TMSs, 43% identical with NIPA1) Mg2+ transport is electrogenic, voltage-dependent, and saturable, a KM of 0.31mM (very selective for Mg2+). (Goytain et al. 2008). As of 2018, the function of this protein as a Mg2+ transporter was under debate (Schäffers et al. 2018).

Accession Number:Q8N8Q9
Protein Name:NIPA2
Length:360
Molecular Weight:39185.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Mg2+

Cross database links:

Genevestigator: Q8N8Q9
eggNOG: prNOG08258
HEGENOM: HBG390220
RefSeq: NP_001008860.1    NP_001008892.1    NP_001008894.1    NP_112184.4   
Entrez Gene ID: 81614   
Pfam: PF05653   
OMIM: 608146  gene
KEGG: hsa:81614   

Gene Ontology

GO:0005769 C:early endosome
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006811 P:ion transport

References (3)

[1] “Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons.”  Chai J.-H.et.al.   14508708
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSQGRGKYDF YIGLGLAMSS SIFIGGSFIL KKKGLLRLAR KGSMRAGQGG HAYLKEWLWW 
61:	AGLLSMGAGE VANFAAYAFA PATLVTPLGA LSVLVSAILS SYFLNERLNL HGKIGCLLSI 
121:	LGSTVMVIHA PKEEEIETLN EMSHKLGDPG FVVFATLVVI VALILIFVVG PRHGQTNILV 
181:	YITICSVIGA FSVSCVKGLG IAIKELFAGK PVLRHPLAWI LLLSLIVCVS TQINYLNRAL 
241:	DIFNTSIVTP IYYVFFTTSV LTCSAILFKE WQDMPVDDVI GTLSGFFTII VGIFLLHAFK 
301:	DVSFSLASLP VSFRKDEKAM NGNLSNMYEV LNNNEESLTC GIEQHTGENV SRRNGNLTAF