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2.A.7.26.1
YnfA of 108 aas and 4 TMSs. YnfA increases the antibiotics' resistance of E. coli strains isolated from the urinary tract, and is an SMR-like drug efflux pump (Sarkar et al. 2015).

Accession Number:P76169
Protein Name:YnfA aka B1582
Length:108
Molecular Weight:11920.00
Species:Escherichia coli [83333]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: P76169
EchoBASE: EB3600
EcoGene: EG13839
eggNOG: COG1742
HEGENOM: HBG313568
RefSeq: AP_002203.1    NP_416099.1   
Entrez Gene ID: 946125   
Pfam: PF02694   
BioCyc: EcoCyc:G6840-MONOMER    ECOL168927:B1582-MONOMER   
KEGG: ecj:JW1574    eco:b1582   

Gene Ontology

GO:0005887 C:integral to plasma membrane

References (4)

[1] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[2] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[3] “Rapid topology mapping of Escherichia coli inner-membrane proteins by prediction and PhoA/GFP fusion analysis.”  Drew D.et.al.   11867724
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MIKTTLLFFA TALCEIIGCF LPWLWLKRNA SIWLLLPAGI SLALFVWLLT LHPAASGRVY 
61:	AAYGGVYVCT ALMWLRVVDG VKLTLYDWTG ALIALCGMLI IVAGWGRT