TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.7.3.6
RhtA (YbiF) Threonine/Homoserine Exporter (may export other amino acids including proline, serine, cysteine, histidine and several amino acid analogues, based on resistance phenotypes (Livshits et al., 2003))

Accession Number:P0AA67
Protein Name:Uncharacterized inner membrane transporter RhtA aka YbiF aka B0813
Length:295
Molecular Weight:31168.00
Species:Escherichia coli [83333]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Threonine, Homoserine

Cross database links:

Genevestigator: P0AA67
EchoBASE: EB2055
EcoGene: EG12134
eggNOG: COG5006
HEGENOM: HBG352302
RefSeq: AP_001444.1    NP_415334.1   
Entrez Gene ID: 947045   
Pfam: PF00892   
BioCyc: EcoCyc:EG12134-MONOMER    ECOL168927:B0813-MONOMER   
KEGG: ecj:JW0798    eco:b0813   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006810 P:transport

References (5)

[1] “Characterization of the sigma 38-dependent expression of a core Escherichia coli starvation gene, pexB.”  Lomovskaya O.L.et.al.   8021175
[2] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MPGSLRKMPV WLPIVILLVA MASIQGGASL AKSLFPLVGA PGVTALRLAL GTLILIAFFK 
61:	PWRLRFAKEQ RLPLLFYGVS LGGMNYLFYL SIQTVPLGIA VALEFTGPLA VALFSSRRPV 
121:	DFVWVVLAVL GLWFLLPLGQ DVSHVDLTGC ALALGAGACW AIYILSGQRA GAEHGPATVA 
181:	IGSLIAALIF VPIGALQAGE ALWHWSVIPL GLAVAILSTA LPYSLEMIAL TRLPTRTFGT 
241:	LMSMEPALAA VSGMIFLGET LTPIQLLALG AIIAASMGST LTVRKESKIK ELDIN