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2.A.7.3.7
The S-adenosylmethionine uptake transporter, Sam (Tucker et al., 2003) (may function by an exchange mechanism (i.e., S-adenosyl-
methionine/S-adenosylhomocysteine exchange))

Accession Number:Q9ZE70
Protein Name:RP076
Length:294
Molecular Weight:33092.00
Species:Rickettsia prowazekii [782]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate S-adenosylmethionine, S-adenosylhomocysteine

Cross database links:

HEGENOM: HBG559298
RefSeq: NP_220470.1   
Entrez Gene ID: 883647   
Pfam: PF00892   
BioCyc: RPRO272947:RP076-MONOMER   
KEGG: rpr:RP076   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006865 P:amino acid transport

References (2)

[1] “S-adenosylmethionine transport in Rickettsia prowazekii.”  Tucker A.M.et.al.   12730161
[2] “The genome sequence of Rickettsia prowazekii and the origin of mitochondria.”  Andersson S.G.E.et.al.   9823893

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MNDALKTYLN GICWFLLSLV TSSINDVMSK YLGTRLHSFE VAFFRFFFSS IVLLPFVVYY 
61:	GKNALKTSRP FVHVLRGLLL FFGMTSWTYG LTIAPVTTAT VVSFAIPLFT LILAVFILNE 
121:	NIIWQRWVVT VVGFIGLVVM LKPHTKDFNP EILYLILAAI SFAMLDIINK KFVVKESMLS 
181:	MLFYSAIVTA MVSLPVAMQY WITPSSFELA LLFVLGSSGS FILFFLLKAF SIVDATATAP 
241:	YRYLELVISA IAAYFIFNEF PDKSTVHGAV IIIPATLFII YSEKKSMSSK HESQ