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2.A.7.7.2
Protein RarD.  Involved in antibiotic resistance (Carruthers et al. 2010).

Accession Number:P27844
Protein Name:Protein rarD
Length:296
Molecular Weight:33283.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Chloramphenicol

Cross database links:

Genevestigator: P27844
EchoBASE: EB1434
EcoGene: EG11466
eggNOG: COG2962
HEGENOM: HOG000262547
Entrez Gene ID: 948330   
Pfam: PF00892   
KEGG: eco:b3819   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005215 F:transporter activity

References (5)

[1] “Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes.”  Daniels D.L.et.al.   1379743
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Escherichia coli K-12: a cooperatively developed annotation snapshot -- 2005.”  Riley M.et.al.   16397293
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDAKQTRQGV LLALAAYFIW GIAPAYFKLI YYVPADEILT HRVIWSFFFM VVLMSICRQW 
61:	SYLKTLIQTP QKIFMLAVSA VLIGGNWLLF IWAVNNHHML EASLGYFINP LVNIVLGMIF 
121:	LGERFRRMQW LAVILAICGV LVQLWTFGSL PIIALGLAFS FAFYGLVRKK IAVEAQTGML 
181:	IETMWLLPVA AIYLFAIADS STSHMGQNPM SLNLLLIAAG IVTTVPLLCF TAAATRLRLS 
241:	TLGFFQYIGP TLMFLLAVTF YGEKPGADKM VTFAFIWVAL AIFVMDAIYT QRRTSK