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2.A.71.1.1
BT1 biopterin/folate (not methotrexate) transporter

Accession Number:Q25272
Protein Name:BT1 aka OrfG
Length:627
Molecular Weight:68931.00
Species:Leishmania donovani [5661]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Biopterin, folate

Cross database links:

Pfam: PF03092   

References (1)

[1] “Increased expression of LD1 genes transcribed by RNA polymerase I in Leishmania donovani as a result of duplication into the rRNA gene locus.”  Lodes M.J.et.al.   8524251

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPPAPESPPP QVAKYVHPVS ARVLRAAPFL GYIPVFSIAI RSFHPKVVVA ICMQRLFEKG 
61:	LANGLMRLSM QPMLTGRYGL TGAMYQRLST LYTLGWALNA FITVMADTFA LFGYTKRWYC 
121:	VVSAVGGGAF ALLYGLLPAK ESSAKPAAAF MFLAALFMSN IDVFAVALYS ERIRQRPAAG 
181:	PALVSWMWGT ALIGIMISSV IQGPLSDNRL THLGVYITAA ILLLSGLLFV FNLFEERRNR 
241:	AARLEDAMIE FLQNTKSAST DSTAGSLPSP HKPDGHLTID SRVEEEGDDD DHDEQKAAAM 
301:	DAQGFVRPRM DTYLCGAVEM NRDVLLRNWR MALFCLILTL GVIANALVNI LGTRWDIMYV 
361:	CIVVAVVVCV SSFFTLPLAI AKAVVFMYFN EILYLNLPGV LNTFYVAKPL CLPGGPHFSY 
421:	TFYNVMNGIL GSIAGIGGTM VFTHLFPHHS YRFVMGLSAV LLPAASMFDL LILKRWNLVI 
481:	GIPDHAMYIL GDAIIYEVCD MLLNMPMMML MCRIAPRGSE SMVFALLASI YHLGTSTSSA 
541:	IGYLLMETIW PVVTQGTCDY SNAPWLVITG HIVAPVFILP LAYVLLPSAR ISDHIDHTGR 
601:	KVMEAALPET RTEAAEEPIA TTMKRDS