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2.A.71.1.2
Biopterin transporter

Accession Number:O76729
Protein Name:BT1
Length:631
Molecular Weight:69281.00
Species:Leishmania mexicana [5665]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Biopterin

Cross database links:

Pfam: PF03092   

References (1)

[1] “Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae.”  Kundig C.et.al.   10228149

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSARYRPPSA PESPPSEMAK YVHPVSARLL RAAPFLGYIP VFSIAIRSFH PNVVLAIFMQ 
61:	RLFEKGLADG LMRLSIQPML TGRYGLTGAM YQRLSTLYTL GWALNAFITV MADTFALFGY 
121:	TKRWYCVVSA VGGSVFALLY GLLPAKELSA KPAAAFMFLA ALFMSNIDVF AVALYSEQIR 
181:	RRPAAGPALV SWMWGTALMG MMISSVIQGP LSDNGLTHFG VYITAGILLL SGLLFVFNLF 
241:	GERPNRAARL EDAMVEFLQH IKSVNGDSTA GSPPSPSKPD GHLTIDSRAE EGEDDDDEQD 
301:	TTATDAQGFV RPRMDTYLCG AVEMNRDAIL RNWRMALFCL ILTLGVIANA LVNILGTQWD 
361:	IMYACIVVAV VVCVSSFFTL PLAIAKAVVF MYFNSIFYLN LPGVLNTFYV ATPSCLPGGP 
421:	HFSYTFYNAI NGILGNIAGI GGTMLFTHLF PNYSYRLVMG LSAVLLPAAS MFDVVILKRW 
481:	NLAIGIPDHA MYIFGDAIIY EVCNMLLNMP MMMLMCRIAP RGSESMVFAL LASIYHLGTS 
541:	TSSAIGYLLM ETIWPVVTQG TCDYSNAPWL VITGHIVTPV FIFPLAYVLL PSVRISDYID 
601:	HTGRKVMEVA LPETRTKAAE EPTATKTRRN S