TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.71.1.1









BT1 biopterin/folate (not methotrexate) transporter
Eukaryota
Kinetoplastida
BT1 (OrfG) of Leishmania donovani
*2.A.71.1.2









Biopterin transporter
Eukaryota
Kinetoplastida
BT1 of Leishmania mexicana
*2.A.71.1.3









FT1 folate/biopterin transporter.  This protein is nearly identical to the functionally characterized protein from L. infantum (2.A.71.1.5) which is a high affinity S-adenosyl methione uptake porter.  Therefore the annotation shown above may be incorrect and this protein may also be an S-adenosyl methionine uptake porter (Dridi et al. 2010). 

Eukaryota
Kinetoplastida
FT1 of Leishmania donovani
*2.A.71.1.4









FT1 (ESAG10) folate/biopterin transporter
Eukaryota
Kinetoplastida
ESAG10 of Trypanosoma brucei
*2.A.71.1.5









High affinity plasma membrane constitutively synthesized S-Adenosylmethionine (AdoMet) uptake transporter, AdoMetT1 of 706 aas. It also takes up the AdoMet analogue, Sinefungin (Dridi et al. 2010).  This protein is nearly identical to 2.A.71.1.3 which may also be an AdoMet uptake transporter (by sequence similarity).

Eukaryota
Kinetoplastida
AdoMetT1 of Leishmania infantum
*2.A.71.2.1









Functionally uncharacterized Orf
Bacteria
Cyanobacteria
Orf of Synechococcus
(PCC7942)
*2.A.71.2.2









Folate/biopterin uptake carrier, Fbp. Transports 5-formyl tetrahydrofolate monoglutamate but not 5-formyltetrahydrofolate triglutamate. (Also transports methotrexate and aminopterin) (Klaus et al., 2005) (Nine homologues are present in Arabidopsis thaliana.) (Klaus et al., 2005). Mutational analyses suggest that the folate binding site involves the core helices 1, 4, 7 and 10 and is in the center of the membrane (Eudes et al., 2010).

Eukaryota
Viridiplantae
Fbp of Arabidopsis thaliana
(Q9SKZ5)
*2.A.71.2.3









Folate/biopterin uptake carrier of 494 aas, Fbp (also transports methotrexate and aminopterin) (Klaus et al., 2005).  Essential residues line the central cavity (based on the LacY structure) in TMSs 1, 4, 7 and 10 (Eudes et al. 2010).

Bacteria
Cyanobacteria
Fbp (Srl0642) of Synechocystic sp. PCC6803 (BAA10362)
*2.A.71.2.4









Folate transporter 3, FT3 of 537 aas and 14 putative TMSs.

Bacteria
Proteobacteria
FT3 of Nitrosospira lacus
*2.A.71.2.5









Uncharacterized protein of 551 aas and 13 - 14 TMSs.

Eukaryota
Oomycetes
UP of Phytophthora parasitica
*2.A.71.3.1









Functionally uncharacterized Orf
Eukaryota
Viridiplantae
Orf of Arabidopsis thaliana