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2.A.71.2.3
Folate/biopterin uptake carrier of 494 aas, Fbp (also transports methotrexate and aminopterin) (Klaus et al., 2005).  Essential residues line the central cavity (based on the LacY structure) in TMSs 1, 4, 7 and 10 (Eudes et al. 2010).

Accession Number:Q55721
Protein Name:Integral membrane protein aka Fbp
Length:494
Molecular Weight:53586.00
Species:Synechocystis sp. (strain PCC 6803)   [1148]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Biopterin, folate, methotrexate, Aminopterin

Cross database links:

eggNOG: COG0477
HEGENOM: HBG411578
RefSeq: NP_442292.1   
Entrez Gene ID: 952517   
Pfam: PF03092   
BioCyc: SSP1148:SLR0642-MONOMER   
KEGG: syn:slr0642   

References (1)

[1] “Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions.”  Kaneko T.et.al.   8905231

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLVAMSMTPI AILFSTPLKR FLREKVLLGN APSWELLAIL SIYFVQGVLG LSRLAVSFFL 
61:	KDELGLSPAA MGALIGLGAA PWILKPVLGL MSDTVPLFGY RRRSYLWLSG LMGSAGWLLF 
121:	AAWVSSGTQA GLVLLFTSLS VAIGDVIVDS LVVERAQRES LAQVGSLQSL TWGAAAVGGI 
181:	ITAYASGALL EWFSTRTVFA ITAIFPLLTV GAAFLISEVS TAEEEEKPQP KAQIKLVWQA 
241:	VRQKTILLPT LFIFFWQATP SAESAFFYFT TNELGFEPKF LGRVRLVTSV AGLIGVGLYQ 
301:	RFLKTLPFRV IMGWSTVISS LLGLTTLILI THANRAMGID DHWFSLGDSI ILTVTGQIAF 
361:	MPVLVLAARL CPPGIEATLF ALLMSVMNLA GVLSFEVGSL LTHWLGVTET QFDNLALLVI 
421:	ITNLSTLLPL PFLGLLPAGD PQVKDKTEKE DNPDDPGDRL VLPPAEVFEH HTVGSLSDQN 
481:	FLPEFFPEKS SSRP