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2.A.72.3.2
K+:H+ symporter, HAK1. Hak1p is produced at high levels but is down regluated by extracellular K and by expression of Trk1 (2.A.38.2.2) (Rivetta et al. 2013).

Accession Number:O74724
Protein Name:Hak1 aka HAK-1
Length:862
Molecular Weight:95542.00
Species:Neurospora crassa [5141]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+, H+

Cross database links:

eggNOG: fuNOG07786
RefSeq: XP_964946.1   
Entrez Gene ID: 3881095   
Pfam: PF02705   
KEGG: ncr:NCU00790   

Gene Ontology

GO:0016020 C:membrane
GO:0015079 F:potassium ion transmembrane transporter act...
GO:0006813 P:potassium ion transport

References (2)

[1] “Cloning of two genes encoding potassium transporters in Neurospora crassa and expression of the corresponding cDNAs in Saccharomyces cerevisiae.”  Haro R.et.al.   10027968
[2] “The genome sequence of the filamentous fungus Neurospora crassa.”  Galagan J.E.et.al.   12712197

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MDNDTTAAPK PSSGPTNTTT TIRIEEPSFP PKDTNDPDRA RDREPATGVS TGVNFRSRGS 
61:	SMSSCHRPEL VGGVFNPRSI ISRGKRPADS RSSHDNGTSQ SHLDIEEGDD WRGGYEKKKQ 
121:	VFKGRTLLWL AYQSVGVIYG DIGTSPLYVF SSTFTAPPTH RDLLQVLSVV IWSITILVTF 
181:	KYIFVILHAD NEGEGGTFSC YSLLTRFANI TERDPREEVT VRMERHLTND LKPPTRSLRA 
241:	KLEGSRFTHV LLKIIGVLAV SMVMSDGVLT PAQSVLGAVQ GLSVVKPDIS KSTVTGTTCG 
301:	ILVLLFLIQP LGTSKIATTF APIVIVWLGL NFSFGIYNLV TFDWTVLKAF SPYFAFQFFI 
361:	EHKTRAWKML GGVLLSFTGV EALFADLGAF SLHAIQLSWM CYTYPCLLLA YIGQAAYISH 
421:	HPDAYTNPFF NAAPPGTLYP SLVIAILAAI VASQAMITAT FQLISQIMKL SYCPQVKVVH 
481:	TSQTFHGQIY VPFVNWLLML GAILVTAVYG DTVKLGNAYG VCVMFVTFFD TCMVTLVSLI 
541:	VWKLSPFLVF VPWLVFASVD GLYLSAALIK VPEGAWFTLT LSGILTSLFL LWRFGKENQW 
601:	RAEAEDRFKP SHLIVKDKNE GGRLRLQPVW GGDPLSSLRG FGIFFDKTGV MTPAVFTHYV 
661:	TKFVAIPEVA VFFHLHPVEA PTVLPEERYA VSHFTAVPGC YRLVIKHGFM DQVISPDLAA 
721:	LIYEQIRRFV VRQATERMRA LEKLRTGEDT DCEGEGEQEA AKGETSHRTE SSGASGPDGV 
781:	LLPVELRDEE AAAELARLDR AYASKILYVV GKEQMRIKTG APIARRFMLS VFLWIRDNTR 
841:	AKIANLQLAT DRLVEVGFVK EI