TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.74.1.1









Lysosomal mouse 4 TMS transporter protein, MTP (transports thymidine, uridine, both purine and pyrimidine nucleosides including adenosine, drugs, ionophores and steroids)
Eukaryota
Metazoa
MTP of Mus musculus
*2.A.74.1.2









Lysosomal 4 TMS retanoic acid-inducible E3 protein.  May play a special functional role during embryogenesis and in adult hematopoietic cells (Adra et al. 1996).

Eukaryota
Metazoa
E3 protein of Mus musculus
*2.A.74.1.3









Lysosomal-associated transmembrane protein 4-beta, LAPTM4B.  Upregulated in many types of cancer cells, in part accounting for multidrug resistance.  Associates with P-Glycoprotein (Li et al. 2010).  May be able to flip lipids from the inner leaflet of the membrane to the outer leaflet, thereby promoting programmed cell death (Blom et al. 2015). This late endosomal protein  controls amino acid transporter interactions (Zhou et al. 2018). The ceramide-mediated regulation of LAPTM4B depends on a sphingolipid interaction motif and an adjacent aspartate residue in the protein's third transmembrane (TMS3) helix. This facilitates the interaction between LAPTM4B and the amino acid transporter heavy chain 4F2hc, thereby controlling mTORC signaling (Zhou et al. 2018).

Eukaryota
Metazoa
LAPTM4B of Homo sapiens
*2.A.74.1.4









Lysosomal-associated transmembrane protein 5 (Lysosomal-associated multitransmembrane protein 5) (Retinoic acid-inducible E3 protein)
Eukaryota
Metazoa
LAPTM5 of Homo sapiens
*2.A.74.1.5









Tri- or tetraspanning orphan receptor (Complement C2 receptor inhibitor tri- or tetraspanning) (SmCRIT; Sm-TOR)

Eukaryota
Metazoa
TOR of Schistosoma mansoni
*2.A.74.1.6









Cartilage matrix protein of 672 aas, 4 N-terminal TMSs (Mtp domain) followed by a large hydrophilic domain with homology to many extracellular proteins in eukaryotes such as von Willebrand factor, integrins (TC# 8.A.54), YegL, TerY, etc. 

Eukaryota
Metazoa
Mtp domain-containing matrix protein of Chelonia mydas (Green sea-turtle) (Chelonia agassizi)
*2.A.74.1.7









Lysosomal-associated transmembrane protein 5 isoform X2 of 240 aas and 5 TM

Eukaryota
Metazoa
UP of  Rousettus aegyptiacus (Egyptian rousette)
*2.A.74.2.1









Uncharacterized protein of 165 aas and 4 TMSs  TMSs 2-4 are homologous to TMSs 2-4 and 5-7 (the two 3 TMS repeats) in TC# 2.A.74.2.6.

Eukaryota
Metazoa
UP of Drosophila melanogaster (Fruit fly)
*2.A.74.2.2









Uncharacterized viral protein of 173 aas and 4 TMSs

Eukaryota
Metazoa
UP of Triatoma matogrossensis
*2.A.74.2.3









Uncharacterized protein of 185 aas and 4 TMSs.

Eukaryota
Metazoa
UP of Danaus plexippus (Monarch butterfly)
*2.A.74.2.4









Uncharacterized protein of 313 aas and 7 TMSs.

Eukaryota
Metazoa
UP of Branchiostoma floridae (Florida lancelet) (Amphioxus)
*2.A.74.2.5









Uncharacterized protein of 301 aas and 7 TMSs.  Either TMSs 1-3 are homologous to TMSs 4-6, and TMS 7 is an extra one, or TMSs 2-4 are homologous to 5-7 and TMS1 is the extra one. Maybe both are true!

Eukaryota
Metazoa
UP of Branchiostoma floridae (Florida lancelet) (Amphioxus)
*2.A.74.2.6









Uncharacterized protein of 404 aas and 6 clear peaks of hydrophobicity plus one or two small peaks preceding each set of homologous 3 TMSs.  The two repeats of 3 large TMSs are homologous to TMSs 2-4 in the 4 TMS homologue, TC# 2.A.74.2.1.

Eukaryota
Metazoa
UP of Branchiostoma floridae (Florida lancelet) (Amphioxus)
*2.A.74.2.7









Uncharacterized protein of 161 aas and 4 TMSs.

Eukaryota
Metazoa
UP of Branchiostoma floridae (Florida lancelet) (Amphioxus)
*2.A.74.2.8









Uncharacterized protein of 551 aas and 12 TMSs in a 6 + 3 + 3 TMS arrangement.

Eukaryota
Metazoa
UP of Branchiostoma floridae (Florida lancelet) (Amphioxus)
*2.A.74.2.9









Uncharacterized protein of 299 aas and 4 N-terminal TMSs

Eukaryota
Metazoa
UP of Harpegnathos saltator (Jerdon's jumping ant)
*2.A.74.2.10









Uncharacterized protein of 196 aas and 4 TMSs.

Eukaryota
Metazoa
UP of Drosophila melanogaster (Fruit fly)