TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.75.1.1









D- and L-lysine, L-histidine and L-arginine exporter (LysE) (Stäbler et al. 2011).  The system may also export L-citrulline (Lubitz et al. 2016).

Bacteria
Actinobacteria
LysE of Corynebacterium glutamicum
*2.A.75.1.2









L-arginine exporter (ArgO or YggA) (Nandineni and Gowrishankar 2004).  ArgP-ArgO of E. coli exhibits transcriptional cross activity with the corresponding pair, LysG-LysE of Corynebacterium glutamicum (Marbaniang and Gowrishankar 2012).  ArgO when overproducted confers sensitivity to the toxic arginine analogue, canavanine and catalyzes export of L-lysine (Pathania and Sardesai 2015). ArgO assumes an Nin-Cout configuration, potentially forming a five-transmembrane helix bundle flanked by a cytoplasmic N-terminal domain (NTD) comprising roughly its first 38 to 43 amino acyl residues and a short periplasmic C-terminal region (CTR). Mutagenesis studies indicate that the CTR, but not the NTD, is dispensable for ArgO function in vivo, and that a pair of conserved aspartate residues, located near the opposing edges of the cytoplasmic membrane, may play a pivotal role in facilitating transmembrane Arg flux (Pathania et al. 2016). ArgO possesses a membrane topology that is distinct from that reported for LysE, with substantial variation in the topological arrangement of the proximal one-third portions of the two exporters. The Arg-translocating conduit is formed by a monomer of ArgO (Pathania et al. 2016).

Bacteria
Proteobacteria
ArgO (YggA) of E. coli
*2.A.75.1.3









Putative amino-acid transporter Rv0488/MT0507
Bacteria
Actinobacteria
Rv0488 of Mycobacterium tuberculosis
*2.A.75.1.4









Canavanine exporter of 202 aas and 6 TMSs, MsiA, promoting canavanine resistance (Cai et al. 2009).  Canavanine is a plant product present in seeds and plant exudates. 

Bacteria
Proteobacteria
MsiA of Mesorhizobium tianshanense