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2.A.8.1.4
D-Gluconate:H+ symporter, GntT (Porco et al., 1997)

Accession Number:P39835
Protein Name:GntT
Length:438
Molecular Weight:45967.00
Species:Escherichia coli [83333]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate D-gluconate

Cross database links:

Genevestigator: P39835
EchoBASE: EB2282
EcoGene: EG12380
eggNOG: COG2610
HEGENOM: HBG649941
RefSeq: AP_004375.1    YP_026217.1   
Entrez Gene ID: 947924   
Pfam: PF02447   
BioCyc: EcoCyc:GNTT-MONOMER   
KEGG: ecj:JW5690    eco:b3415   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015128 F:gluconate transmembrane transporter activity
GO:0019521 P:D-gluconate metabolic process
GO:0015725 P:gluconate transport

References (9)

[1] “Analysis of the Escherichia coli gntT and gntU genes and comparison of the products with their homologues.”  Yamada M.et.al.   8987614
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Escherichia coli K-12: a cooperatively developed annotation snapshot -- 2005.”  Riley M.et.al.   16397293
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Molecular characterization of malQ, the structural gene for the Escherichia coli enzyme amylomaltase.”  Pugsley A.P.et.al.   2845225
[6] “Intrinsic and extrinsic approaches for detecting genes in a bacterial genome.”  Borodovsky M.et.al.   7984428
[7] “Mutations affecting gluconate catabolism in Escherichia coli. Genetic mapping of the locus for the thermosensitive gluconokinase.”  Isturiz T.et.al.   3040894
[8] “Molecular genetic characterization of the Escherichia coli gntT gene of GntI, the main system for gluconate metabolism.”  Porco A.et.al.   9045817
[9] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPLVIVAIGV ILLLLLMIRF KMNGFIALVL VALAVGLMQG MPLDKVIGSI KAGVGGTLGS 
61:	LALIMGFGAM LGKMLADCGG AQRIATTLIA KFGKKHIQWA VVLTGFTVGF ALFYEVGFVL 
121:	MLPLVFTIAA SANIPLLYVG VPMAAALSVT HGFLPPHPGP TAIATIFNAD MGKTLLYGTI 
181:	LAIPTVILAG PVYARVLKGI DKPIPEGLYS AKTFSEEEMP SFGVSVWTSL VPVVLMAMRA 
241:	IAEMILPKGH AFLPVAEFLG DPVMATLIAV LIAMFTFGLN RGRSMDQIND TLVSSIKIIA 
301:	MMLLIIGGGG AFKQVLVDSG VDKYIASMMH ETNISPLLMA WSIAAVLRIA LGSATVAAIT 
361:	AGGIAAPLIA TTGVSPELMV IAVGSGSVIF SHVNDPGFWL FKEYFNLTIG ETIKSWSMLE 
421:	TIISVCGLVG CLLLNMVI