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2.A.81.1.1
The L-aspartate:L-alanine exchanger, AspT.  A mutant, R76K, has higher activity than the AspT-WT (R76), whereas R76D and R76E have lower activity than AspT-WT. Thus, R76 is involved in AspT substrate transport (Suzuki et al. 2016).

Accession Number:Q8L3K8
Protein Name:AspT
Length:543
Molecular Weight:57213.00
Species:Tetragenococcus halophilus (Pediococcus halophilus) [51669]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate L-aspartate, L-alanine

Cross database links:

Pfam: PF06826   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0006810 P:transport

References (1)

[1] “Plasmid-encoded asp operon confers a proton motive metabolic cycle catalyzed by an aspartate-alanine exchange reaction.”  Abe K.et.al.   12003930

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNAIGNFLVG TPVFTIFICL ALGYLLGKLK IGSFTLGATV GVLIVALLIG QLGVFPRDTL 
61:	LGDIFFDFFM FAIGYRVGPS FISSMKKFGA KIVYATLIFL VSAFIVAYAC FKMFHIGPGI 
121:	AAGIIAGGLT QSAVIGSSLE TISKLPISDH LKTLYSNQIP IVYTLTYVFG TIGVLIFLRD 
181:	IMPKLMHIDL KKQAVKTAKE LDMIPVPVIV ASTHFYTIND GSSLIGQTLG TVNTKFAKGL 
241:	VAAGLNDSAD MASVINAGDV LAISGGIDEI GRAVQEFNLL EVTGKTKAYV SKQVVLKKNF 
301:	SADVLKNAQD KGVLVATLAG DVMDPAQFST LKPAESVTLV GQKDAVSEVQ SQLGRLRAAE 
361:	NIINYSWFAL GIALSAALGI VGTKVSGVPI ALGGGTASLI VGLVQSIYRD KHAHMDTIPD 
421:	SLLEFFQSIG LNLFIATVGL SAAKTFISAI QSMGISVLLI GAVISILPHI ITFVICYYLM 
481:	KMEPISIIGA QTGADTLSAA LNDVSERVGS DASPFFAAAV APAYAIGNIF LTLMGPIFIV 
541:	LLS