TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.85.1.2
p-hydroxybenzoate efflux carrier, AaeB (Van Dyk et al., 2004). Several aromatic carboxylic acids serve as inducers of yhcRQP operon expression.

Accession Number:P46481
Protein Name:YhcP aka B3240
Length:655
Molecular Weight:73591.00
Species:Escherichia coli [83333]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate p-Hydroxybenzoate

Cross database links:

Genevestigator: P46481
EchoBASE: EB2673
EcoGene: EG12822
eggNOG: COG1289
HEGENOM: HBG417090
RefSeq: AP_003782.1    NP_417707.1   
Entrez Gene ID: 947747   
Pfam: PF04632   
BioCyc: EcoCyc:G7685-MONOMER    ECOL168927:B3240-MONOMER   
KEGG: ecj:JW3209    eco:b3240   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0046942 P:carboxylic acid transport
GO:0042221 P:response to chemical stimulus

References (4)

[1] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[2] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[3] “Characterization of the Escherichia coli AaeAB efflux pump: a metabolic relief valve?”  Van Dyk T.K.et.al.   15489430
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MGIFSIANQH IRFAVKLATA IVLALFVGFH FQLETPRWAV LTAAIVAAGT AFAAGGEPYS 
61:	GAIRYRGFLR IIGTFIGCIA GLVIIIAMIR APLLMILVCC IWAGFCTWIS SLVRIENSYA 
121:	WGLAGYTALI IVITIQPEPL LTPQFAVERC SEIVIGIVCA IMADLLFSPR SIKQEVDREL 
181:	ESLLVAQYQL MQLCIKHGDG EVVDKAWGDL VRRTTALQGM RSNLNMESSR WARANRRLKA 
241:	INTLSLTLIT QSCETYLIQN TRPELITDTF REFFDTPVET AQDVHKQLKR LRRVIAWTGE 
301:	RETPVTIYSW VAAATRYQLL KRGVISNTKI NATEEEILQG EPEVKVESAE RHHAMVNFWR 
361:	TTLSCILGTL FWLWTGWTSG SGAMVMIAVV TSLAMRLPNP RMVAIDFIYG TLAALPLGLL 
421:	YFLVIIPNTQ QSMLLLCISL AVLGFFLGIE VQKRRLGSMG ALASTINIIV LDNPMTFHFS 
481:	QFLDSALGQI VGCVLAFTVI LLVRDKSRDR TGRVLLNQFV SAAVSAMTTN VARRKENHLP 
541:	ALYQQLFLLM NKFPGDLPKF RLALTMIIAH QRLRDAPIPV NEDLSAFHRQ MRRTADHVIS 
601:	ARSDDKRRRY FGQLLEELEI YQEKLRIWQA PPQVTEPVNR LAGMLHKYQH ALTDS