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2.A.85.2.3
The root aluminum-activated malate efflux transporter, ALMT1 (required for aluminum tolerance) (Hoekenga et al., 2006).  Also called Quick Anion Channel, QUAC, based on activation kinetics of anion channel currents in response to voltage changes.  Evolutionary studies have been reported (Dreyer et al. 2012).  Plants respond to aluminum (Al) ions by releasing malate from their root apices via ALMT1 with malate bound to the toxic Al ions, contributing to Al tolerance (Sasaki et al. 2014).

Accession Number:Q15EV0
Protein Name:Aluminum activated malate transporter aka ALMT1
Length:493
Molecular Weight:55047.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Al3+, malate

Cross database links:

Genevestigator: Q15EV0
Pfam: PF11744   

Gene Ontology

GO:0010044 P:response to aluminum ion

References (1)

[1] “AtALMT1, which encodes a malate transporter, is identified as one of several genes critical for aluminum tolerance in Arabidopsis.”  Hoekenga O.A.et.al.   16740662

External Searches:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEKVREIVRE GIRVGNEDPR RIIHAFKVGL ALVLVASFYY YQPFGPFTDY FGINAMWAVM 
61:	TVVVVFEFSV GATLGKGLNR GVATLVAGGL GIGAHQLARL SGATVEPILL VMLVFVQAAL 
121:	STFVRFFPWV KTKFDYGILI FILTFALISL SGFRDEEIMD LAESRLSTVV IGGVSCILIS 
181:	IFVCPVWAGQ DLHSLLASNF DTLSHFLQDF GDEYFEAREK GDYKVVEKRK KNLERYKSVL 
241:	DSKSDEEALA NYAEWEPPHG QFRFRHPWKQ YVAVGALLRQ CAYRIDALNS YINSDFQVPV 
301:	DIKKKLETPL RRMSSESGNS MKEMSISLKQ MIKSSSSDIH VSNSQAACKS LSTLLKSGIL 
361:	NDVEPLQMIS LMTTVSMLID IVNLTEKISE SVHELASAAR FKNKMRPTVL YEKSDSGSIG 
421:	RAMPIDSHED HHVVTVLHDV DNDRSNNVDD SRGGSSQDSC HHVAIKIVDD NSNHEKHEDG 
481:	EIHVHTLSNG HLQ