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2.A.85.2.5
Aluminum-stimulated anion (Malate >> NO3- > Cl-; Malate/Cl- ≈ 20) channel (Zhang et al., 2008) (67% identical to 2.A.85.2.4). Confers Al+3 resistance (Ryan et al., 2011). May also transport a variety of organic and inorganic anions (Piñeros et al. 2008). It can also transport GABA (Ramesh et al. 2018). ALMT1 has 6 TMSs with the N- and C-termini being on the external surface of the plasma membrane (Motoda et al. 2007).

Accession Number:Q76LB2
Protein Name:ALMT1
Length:459
Molecular Weight:49673.00
Species:Triticum aestivum (Wheat) [4565]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate malate, nitrate, Cl-, Al3+

Cross database links:

Pfam: PF11744   

Gene Ontology

GO:0010044 P:response to aluminum ion

References (2)

[1] “A wheat gene encoding an aluminum-activated malate transporter.”  Sasaki T.et.al.   14871306
[2] “Molecular characterization and mapping of ALMT1, the aluminium-tolerance gene of bread wheat (Triticum aestivum L.).”  Raman H.et.al.   16391684

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDIDHGRESD GEMVGTIASC GLLLHSLLAG LGRRAAGFAR KVGGAAREDP RRVAHSLKVG 
61:	LALALVSVVY FVTPLFNGLG VSAIWAVLTV VVVMEYTVGA TLSKGLNRAL ATLVAGCIAV 
121:	GAHQLAELAE RCGDQGEPIM LTVLVFFVAS AATFLRFIPE IKAKYDYGVT IFILTFGLVA 
181:	VSSYRVEELI QLAHQRFYTI AVGVFICLCT TVFLFPVWAG EDVHKLASGN LDKLAQFIEG 
241:	MEFNCFGENS VANNFGGKDF PQMHKSVLNS KATEDSLCTF AKWEPRHGQF RFRHPWSQYQ 
301:	KLGTLCRQCA SSMEALASYV ITTSKTQCPA AANPELSCKV RKTCGEMSLH SSKVLRDLAM 
361:	ATRTMTVPSP VNITMATAVK AAESLRSELA ENTALLQVMH VAVTATLLAD LVDRVKEIAE 
421:	CVDVLARLAH FKNPEDTKNV VVSTVSRGID EPLPDVVIL