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 2.A.86 The Autoinducer-2 Exporter (AI-2E) Family (formerly the PerM Family, TC #9.B.22)

  The AI-2E family (UPF0118) is a large family of prokaryotic proteins derived from a variety of bacteria and archaea. Those examined are about 350 residues in length, and the couple that have been examined exhibit 7 putative transmembrane α-helical spanners (TMSs) (Rettner and Saier, 2010). E. coli, B. subtilis and several other prokaryotes have multiple paralogues encoded within their genomes. Herzberg et al. (2006) have presented strong evidence for a role of a AI-2E family homologue, YdgG (renamed TqsA), as an exporter of the E. coli autoinducer-2 (AI-2) (Camilli and Bassler, 2006; Chen et al., 2002). AT-2 is a proposed signalling molecule for interspecies communication in bacteria. It is a furanosyl borate diester (Chen et al., 2002). It is induced in Bacillus subtilis by exposure to rice seedlings (Xie et al. 2015).  

The transport reaction catalyzed by TqsA is:

AI-2 (in) ⇌ AI-2 (out)

References associated with 2.A.86 family:

Besse A., Peduzzi J., Rebuffat S. and Carre-Mlouka A. (2015). Antimicrobial peptides and proteins in the face of extremes: Lessons from archaeocins. Biochimie. 118:344-55. 26092421
Camilli, A. and Bassler, B.L. (2006). Bacterial small-molecule signaling pathways. Science 311: 1113-1116. 16497924
Chen, X., S. Schauder, N. Potier, A. Van Dorsselaer, I. Pelczer, B.L. Bassler, and F.M. Hughson. (2002). Structural identification of a bacterial quorum-sensing signal containing boron. Nature 415: 488-489. 11823863
Eichenberger, P., S.T. Jensen, E.M. Conlon, C. van Ooij, J. Silvaggi, J.E. González-Pastor, M. Fujita, S. Ben-Yehuda, P. Stragier, J.S. Liu, and R. Losick. (2003). The sigmaE regulon and the identification of additional sporulation genes in Bacillus subtilis. J. Mol. Biol. 327: 945-972. 12662922
Herzberg, M., I.K. Kaye, W. Peti, and T.K. Wood. (2006). YdgG (TqsA) controls biofilm formation in Escherichia coli K-12 through autoinducer 2 transport. J. Bacteriol. 188: 587-598. 16385049
Nobre, L.S., F. Al-Shahrour, J. Dopazo, and L.M. Saraiva. (2009). Exploring the antimicrobial action of a carbon monoxide-releasing compound through whole-genome transcription profiling of Escherichia coli. Microbiology 155: 813-824. 19246752
Ravcheev, D.A., M.S. Gel'fand, A.A. Mironov, and A.B. Rakhmaninova. (2002). [Purine regulon of γ-proteobacteria: a detailed description]. Genetika 38: 1203-1214. 12391881
Rettner, R.E. and M.H. Saier, Jr. (2010). The autoinducer-2 exporter superfamily. J. Mol. Microbiol. Biotechnol. 18: 195-205. 20559013
Turner, M.S. and J.D. Helmann. (2000). Mutations in multidrug efflux homologs, sugar isomerases, and antimicrobial biosynthesis genes differentially elevate activity of the σX and σW factors in Bacillus subtilis. J. Bacteriol. 182: 5202-5210. 10960106
Xie, S., H. Wu, L. Chen, H. Zang, Y. Xie, and X. Gao. (2015). Transcriptome profiling of Bacillus subtilis OKB105 in response to rice seedlings. BMC Microbiol 15: 21. 25651892