TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.87.1.1









The riboflavin uptake transporter, RibU (may also transport roseoflavin and flavin mononucleotide (FMN)) (Burgess et al., 2006). Substrates noted above bind RibU with nM (Vitamin B2 with 0.6 nM) affinity with 1:1 stoichiometry; FAD does not bind (Duurkens et al., 2007).
Bacteria
Firmicutes
RibU of Lactococcus lactis (AAY43361)
*2.A.87.1.2









Riboflavin transporter RibU (Riboflavin ECF transporter S component RibU or YpaA). Regulated by FMN riboswitch (Rodionov et al. 2009). RibU-mediated riboflavin uptake was sensitive to protonophores and reduced in the absence of glucose, demonstrating that the protein requires metabolic energy for substrate translocation (Vogl et al. 2007).

Bacteria
Firmicutes
RibU of Bacillus subtilis (P50726)
*2.A.87.1.3









Riboflavin ECF Transporter, RibU. The substrate-binding component (S) has been solved by x-ray crystallography (Zhang et al., 2010).

Bacteria
Firmicutes
RibU of Staphylococcus aureus (D3EWM9)
*2.A.87.1.4









The riboflavin transporter of 203 aas and 5 TMSs, RibU or EcfS. Mediates riboflavin and maybe also FMN and roseoflavin uptake. Interacts with the energy-coupling factor (ECF) module, EcfAA'T, which energizes transport of a number of different substrates, each with its own EcfS subunit.  Does not use an extracytoplasmic receptor (Karpowich et al. 2015).

Bacteria
Firmicutes
Riboflavin transporter of Listeria monocytogenes
*2.A.87.2.1









Pantothenate transporter PanT (Pantothenic acid ECF transporter S component PanT).  A similar pantothenate transporter, also called PanT, has been characterized in Lactobacillus brevis (Zhang et al. 2014).

Bacteria
Firmicutes
PanT of Leuconostoc mesenteroides (Q03YI6)  
*2.A.87.2.3









Putative Thiamine Transporter, ThiA (Duf165; YuaJ) (187 aas; 6 TMSs)

Bacteria
Firmicutes
ThiA of Streptococcus mitis (F9LXW4)
*2.A.87.3.1









Uncharacterized protein of 172 aas and 5 TMSs

Bacteria
Firmicutes
UP of Clostridium kluyveri
*2.A.87.3.2









Putative heptaprenyl diphosphate synthase component I of 173 aas and 5 TMSs. 

Bacteria
Firmicutes
P-RFT family member of Clostridium leptum
*2.A.87.3.3









Uncharacterized protein of 169 aas and 5 TMSs.

Bacteria
Tenericutes
UP of Acholeplasma laidlawii
*2.A.87.4.1









Riboflavin uptake transporter of 228 aas and 5 TMSs (Gutiérrez-Preciado et al. 2015).

Bacteria
Tenericutes
RibV of Mesoplasma florum
*2.A.87.4.2









Putative riboflavin transporter of 227 aas and 5 TMSs (Gutiérrez-Preciado et al. 2015).

Bacteria
Tenericutes
RibV of Mycoplasma capricolum
*2.A.87.4.3









Uncharacterized protein, probably a riboflavin transporter of 234 aas and 5 TMSs.

Bacteria
Tenericutes
UP of Spiroplasma citri