TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.89.1.1









The vacuolar Fe2+/Mn2+ uptake transporter, Ccc1
Eukaryota
Fungi
Ccc1 of Saccharomyces cerevisiae (322 aas; P47818)
*2.A.89.1.2









The vacuolar Fe2+ uptake transporter, VIT1 of 250 aas and 5 putative TMSs (Gollhofer et al. 2011). The crystal structure of the orthogous VIT1 from rose gum, Eucalyptus grandis, which probably functions as a H+-dependent antiporter for Fe2+ and other transition metal ions, has been solved. VIT1 adopts a novel protein fold forming a dimer of five membrane-spanning domains, with an ion-translocating pathway constituted by the conserved methionine and carboxylate residues at the dimer interface. The second transmembrane helix protrudes from the lipid membrane by about 40 Å, and connects to a three-helical bundle, triangular, cytoplasmic domain, which binds to the substrate metal ions in preparation for their transport (Kato et al. 2019).

Eukaryota
Viridiplantae
VIT1 of Arabidopsis thaliana (Q9ZUA5)
*2.A.89.1.3









Uncharacterized protein of 242 aas and 5 TMSs

Bacteria
Bacteroidetes/Chlorobi group
Uncharacterized protein of Marivirga tractuosa
*2.A.89.1.4









Uncharacterized protein of 252 aas with 5 TMSs

Bacteria
Chlamydiae/Verrucomicrobia group
Uncharacterized protein of Parachlamydia acanthamoebae
*2.A.89.1.5









CCC1 (VIT) family protein of 248 aas

Bacteria
Chlamydiae/Verrucomicrobia group
VIT family protein of Chlamydia trachomatis
*2.A.89.1.6









Uncharacterized protein of 173 aas and 5 TMSs.

Bacteria
Candidatus Sungbacteria
UP of Candidatus Sungbacteria bacterium
*2.A.89.2.1









Bacteria
Proteobacteria
VIT family member of Rhizobium leguminosarum
*2.A.89.2.2









Membrane-bound ferritin-like ferrous iron (Fe2+) exporter, MbfA, of the erythrin-vacuolar iron transport-1 (Er-VIT1) family of 327 aas.  The protein has an N-terminal ferritin domain and a C-terminal VIT domain of 5 established TMSs (Bhubhanil et al. 2014).

Bacteria
Proteobacteria
MbfA of Agrobacterium tumefaciens
*2.A.89.2.3









VIT family member of 2690 aas and 5 TMSs.

Bacteria
Proteobacteria
VIT of Bartonella clarridgeiae
*2.A.89.3.1









The bacterial VIT family homologue

Bacteria
Proteobacteria
VIT homologue of Burkholderia phytofirmans (376 aas; B2TCH9)
*2.A.89.3.2









VIT family member, Spr0814 (Becker et al., 2009).

Bacteria
Firmicutes
Spr0814, VIT family member of Streptococcus pneumoniae (E1H0W3)
*2.A.89.3.3









Vacuolar Nodulin-like1 (At1g21140) Iron regulated (Gollhofer et al., 2011).

Eukaryota
Viridiplantae
VIT homolog1 of Arabidopsis thaliana (Q9LPU9)
*2.A.89.3.4









Nodulin-like2 (At1g76800) Iron regulated (Gollhofer et al., 2011).

Eukaryota
Viridiplantae
VIT homolog2 of Arabidopsis thaliana (Q9SR03)
*2.A.89.3.5









Nodulin-like2.1 (At3g25190) Iron regulated; involved in Fe homeostasis (Gollhofer et al., 2011).

Eukaryota
Viridiplantae
VIT homolog2.1 of Arabidopsis thaliana (Q9LSF6)
*2.A.89.3.6









Nodulin-like3 (At3g43630) Not iron regulated; involved in Fe homeostasis (Gollhofer et al., 2011).

Eukaryota
Viridiplantae
VIT3 of Arabidopsis thaliana (Q9M2C3)
*2.A.89.3.7









Nodulin-like4 (At3g43660) Not iron regulated (Gollhofer et al., 2011).

Eukaryota
Viridiplantae
VIT4 of Arabidopsis thaliana (Q9M2C0)
*2.A.89.3.8









Fe2+/Mn2+ transporter Pcl1 (Pombe ccc1-like protein 1)

Eukaryota
Fungi
Pcl1 of Schizosaccharomyces pombe
*2.A.89.3.9









VIT family protein of 413 aas with an N-terminal rubrerythrin-like (ferritin-like) domain and a C-terminal DUF125 (5 TMS) domain.

Bacteria
Chlamydiae/Verrucomicrobia group
VIT family protein of Methylacidiphilum infernorum (Methylokorus infernorum)
*2.A.89.3.10









The archaeal VIT family homologue
Archaea
Euryarchaeota
VIT homologue of Pyrococcus abyssi (364 aas; CAB50539)