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2.A.89.1.1
The vacuolar Fe2+/Mn2+ uptake transporter, Ccc1

Accession Number:P47818
Protein Name:Ccc1 aka YLR220W
Length:322
Molecular Weight:34250.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate Fe2+, Mn2+

Cross database links:

Genevestigator: P47818
eggNOG: fuNOG07917
HEGENOM: HBG748253
DIP: DIP-782N
RefSeq: NP_013321.1   
Entrez Gene ID: 850917   
Pfam: PF01988   
KEGG: sce:YLR220W   

Gene Ontology

GO:0000329 C:fungal-type vacuole membrane
GO:0000139 C:Golgi membrane
GO:0016021 C:integral to membrane
GO:0015093 F:ferrous iron transmembrane transporter acti...
GO:0005384 F:manganese ion transmembrane transporter act...
GO:0005515 F:protein binding
GO:0006874 P:cellular calcium ion homeostasis
GO:0006879 P:cellular iron ion homeostasis
GO:0030026 P:cellular manganese ion homeostasis
GO:0015684 P:ferrous iron transport
GO:0006828 P:manganese ion transport

References (19)

[1] “Sequence, mapping and disruption of CCC1, a gene that cross-complements the Ca(2+)-sensitive phenotype of csg1 mutants.”  Fu D.et.al.   7941738
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.”  Johnston M.et.al.   9169871
[3] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[4] “The product of HUM1, a novel yeast gene, is required for vacuolar Ca2+/H+ exchange and is related to mammalian Na+/Ca2+ exchangers.”  Pozos T.C.et.al.   8668190
[5] “The role of the Saccharomyces cerevisiae CCC1 gene in the homeostasis of manganese ions.”  Lapinskas P.J.et.al.   8866476
[6] “CCC1 suppresses mitochondrial damage in the yeast model of Friedreich's ataxia by limiting mitochondrial iron accumulation.”  Chen O.S.et.al.   10713071
[7] “CCC1 is a transporter that mediates vacuolar iron storage in yeast.”  Li L.et.al.   11390404
[8] “Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae.”  Ficarro S.B.et.al.   11875433
[9] “Global analysis of protein localization in budding yeast.”  Huh W.-K.et.al.   14562095
[10] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[11] “A proteomics approach to understanding protein ubiquitination.”  Peng J.et.al.   12872131
[12] “A mitochondrial-vacuolar signaling pathway in yeast that affects iron and copper metabolism.”  Li L.et.al.   15161905
[13] “Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation.”  Puig S.et.al.   15652485
[14] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[15] “Golgi manganese transport is required for rapamycin signaling in Saccharomyces cerevisiae.”  Devasahayam G.et.al.   17603109
[16] “Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.”  Li X.et.al.   17330950
[17] “Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.”  Smolka M.B.et.al.   17563356
[18] “Yap5 is an iron-responsive transcriptional activator that regulates vacuolar iron storage in yeast.”  Li L.et.al.   18070921
[19] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSIVALKNAV VTLIQKAKGS GGTSELGGSE STPLLRGSNS NSSRHDNLSS SSSDIIYGRN 
61:	SAQDLENSPM SVGKDNRNGD NGSDNEKANL GFFQSVDPRV ISDLIIGLSD GLTVPFALTA 
121:	GLSSLGDAKL VITGGFAELI SGAISMGLGG YLGAKSESDY YHAEVKKEKR KFYDNSNLIN 
181:	REIEDILLEI NPNFSDETIV SFIKDLQRTP ELMVDFIIRY GRGLDEPAEN RELISAVTIG 
241:	GGYLLGGLVP LVPYFFVSDV GTGLIYSIIV MVVTLFWFGY VKTKLSMGSG SSTSKKVTEG 
301:	VEMVVVGGVA AGAAWFFVKL LG