TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.89.3.8
Fe2+/Mn2+ transporter Pcl1 (Pombe ccc1-like protein 1)

Accession Number:Q9P6J2
Protein Name:Fe(2+)/Mn(2+) transporter pcl1
Length:242
Molecular Weight:25625.00
Species:Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [284812]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Endoplasmic reticulum1
Substrate Fe2+, Mn2+

Cross database links:

eggNOG: COG1814
HEGENOM: HOG000096548
Entrez Gene ID: 2539895   
Pfam: PF01988   
KEGG: spo:SPBC1683.10   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0005794 C:Golgi apparatus
GO:0000139 C:Golgi membrane
GO:0016021 C:integral to membrane
GO:0005774 C:vacuolar membrane
GO:0015093 F:ferrous iron transmembrane transporter activity
GO:0006874 P:cellular calcium ion homeostasis
GO:0006879 P:cellular iron ion homeostasis
GO:0030026 P:cellular manganese ion homeostasis
GO:0070627 P:ferrous iron import
GO:0071421 P:manganese ion transmembrane transport

References (4)

[1] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360
[2] “A transcription factor cascade involving Fep1 and the CCAAT-binding factor Php4 regulates gene expression in response to iron deficiency in the fission yeast Schizosaccharomyces pombe.”  Mercier A.et.al.   16963626
[3] “ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.”  Matsuyama A.et.al.   16823372
[4] “Phosphoproteome analysis of fission yeast.”  Wilson-Grady J.T.et.al.   18257517

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MWSIFEARPK EAHSVNKIGW LRASVLGAND GILSLSGLLV GVVAANADIK VILITGVAGL 
61:	MSGALSMAVG EYVSVSSQAD LEDADLQLER REMDADWDAE VDELAAIYRG RGLDEELSRT 
121:	VAVQLMEYNA LEAHARDELG INIHTTAKPT LAALSSAASF SVGGIFPLLT SLITPLEYLS 
181:	LVLPIATMFF LGMLGFVGAH IGGAKRVRAI LRAVVLGLLA MAATALVGRL LEIHALSLQY 
241:	AI