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2.A.9.1.1
Cytochrome oxidase biogenesis protein, Oxa1p (involved in the insertion of a wide range of membrane proteins).  Forms a cation-selective channel (4-state; diameter, 0.6 - 2.0 nm), regulated by the membrane potential and association with the substrate protein (Krüger et al. 2012).  The structure of the dimeric insertion pore associated with the translating ribosome has been solved (Kohler et al. 2009).

Accession Number:P39952
Protein Name:OXA1 aka Oxa1p aka PET1402 aka YER154W
Length:402
Molecular Weight:44816.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate proteins

Cross database links:

Genevestigator: P39952
eggNOG: fuNOG04575
HEGENOM: HBG397675
DIP: DIP-3870N
RefSeq: NP_011081.1   
Entrez Gene ID: 856898   
Pfam: PF02096   
KEGG: sce:YER154W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0032977 F:membrane insertase activity
GO:0043022 F:ribosome binding
GO:0033615 P:mitochondrial proton-transporting ATP synth...
GO:0032979 P:protein insertion into mitochondrial membra...

References (9)

[1] “OXA1, a Saccharomyces cerevisiae nuclear gene whose sequence is conserved from prokaryotes to eukaryotes controls cytochrome oxidase biogenesis.”  Bonnefoy N.et.al.   8196054
[2] “PET1402, a nuclear gene required for proteolytic processing of cytochrome oxidase subunit 2 in yeast.”  Bauer M.et.al.   7816036
[3] “The nucleotide sequence of Saccharomyces cerevisiae chromosome V.”  Dietrich F.S.et.al.   9169868
[4] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[5] “Insertion into the mitochondrial inner membrane of a polytopic protein, the nuclear-encoded Oxa1p.”  Herrmann J.M.et.al.   9171337
[6] “Oxa1p, an essential component of the N-tail protein export machinery in mitochondria.”  Hell K.et.al.   9482871
[7] “Yeast Oxa1 interacts with mitochondrial ribosomes: the importance of the C-terminal region of Oxa1.”  Jia L.et.al.   14657017
[8] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[9] “Insertion of proteins into the inner membrane of mitochondria: the role of the Oxa1 complex.”  Stuart R.A.et.al.   12191770

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFKLTSRLVT SRFAASSRLA TARTIVLPRP HPSWISFQAK RFNSTGPNAN DVSEIQTQLP 
61:	SIDELTSSAP SLSASTSDLI ANTTQTVGEL SSHIGYLNSI GLAQTWYWPS DIIQHVLEAV 
121:	HVYSGLPWWG TIAATTILIR CLMFPLYVKS SDTVARNSHI KPELDALNNK LMSTTDLQQG 
181:	QLVAMQRKKL LSSHGIKNRW LAAPMLQIPI ALGFFNALRH MANYPVDGFA NQGVAWFTDL 
241:	TQADPYLGLQ VITAAVFISF TRLGGETGAQ QFSSPMKRLF TILPIISIPA TMNLSSAVVL 
301:	YFAFNGAFSV LQTMILRNKW VRSKLKITEV AKPRTPIAGA SPTENMGIFQ SLKHNIQKAR 
361:	DQAERRQLMQ DNEKKLQESF KEKRQNSKIK IVHKSNFINN KK