TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.9.1.2
Mammalian Oxa1L has a C-terminal 100 aa tail that binds ribosomes and promotes translation coupled membrane insertion (Haque et al., 2010).

Accession Number:Q15070
Protein Name:Mitochondrial inner membrane protein OXA1L
Length:435
Molecular Weight:48548.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate proteins

Cross database links:

Genevestigator: Q15070
eggNOG: prNOG08812
Entrez Gene ID: 5018   
Pfam: PF02096   
KEGG: hsa:5018   

Gene Ontology

GO:0032592 C:integral to mitochondrial membrane
GO:0005746 C:mitochondrial respiratory chain
GO:0043234 C:protein complex
GO:0009060 P:aerobic respiration
GO:0033615 P:mitochondrial proton-transporting ATP synth...
GO:0032981 P:mitochondrial respiratory chain complex I a...
GO:0032780 P:negative regulation of ATPase activity
GO:0051354 P:negative regulation of oxidoreductase activity
GO:0055114 P:oxidation reduction
GO:0051205 P:protein insertion into membrane

References (4)

[1] “Cloning of a human gene involved in cytochrome oxidase assembly by functional complementation of an oxa1- mutation in Saccharomyces cerevisiae.”  Bonnefoy N.et.al.   7991568
[2] “Sequence and structure of the human OXA1L gene and its upstream elements.”  Roetig A.et.al.   9247084
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MAMGLMCGRR ELLRLLQSGR RVHSVAGPSQ WLGKPLTTRL LFPVAPCCCR PHYLFLAASG 
61:	PRSLSTSAIS FAEVQVQAPP VVAATPSPTA VPEVASGETA DVVQTAAEQS FAELGLGSYT 
121:	PVGLIQNLLE FMHVDLGLPW WGAIAACTVF ARCLIFPLIV TGQREAARIH NHLPEIQKFS 
181:	SRIREAKLAG DHIEYYKASS EMALYQKKHG IKLYKPLILP VTQAPIFISF FIALREMANL 
241:	PVPSLQTGGL WWFQDLTVSD PIYILPLAVT ATMWAVLELG AETGVQSSDL QWMRNVIRMM 
301:	PLITLPITMH FPTAVFMYWL SSNLFSLVQV SCLRIPAVRT VLKIPQRVVH DLDKLPPREG 
361:	FLESFKKGWK NAEMTRQLRE REQRMRNQLE LAARGPLRQT FTHNPLLQPG KDNPPNIPSS 
421:	SSKPKSKYPW HDTLG