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2.A.9.3.6
YidC2.  The 3-D structure of YidC has been determined (Kumazaki et al. 2014).  The conserved positively charged residue within transmembrane segment one (at position 72) is located in a hydrophilic groove that is embedded in the inner leaflet of the lipid bilayer.  It is essential in Gram positive bacteria but not Gram negative bacteria or plant chloroplasts (Chen et al. 2014).

Accession Number:Q9KDP2
Protein Name:Membrane protein insertase YidC 2
Length:280
Molecular Weight:32108.00
Species:Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [272558]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate proteins

Cross database links:

Structure:
3WO6   3WO7     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNYMKRRLLL FAGILLLVAL AGCSTTDPIT SESEGIWNHF FVYPMSWLIT TVANLLNGSY 
61:	GLSIIIVTIL IRLALLPLTL KQQKSMRAMQ VIRPEMEAIQ KKYKEKGSKD PKVQQEMQKE 
121:	LLGLYQKHGV NPMAGCLPLF IQLPILMAFY FAIMRTEEIR YHTFLWFDLG QPDYILPFVA 
181:	GITTYFQFKM TMSHQQQMQK TNPSDSDNPM ANMMQMQMKV MLYVMPVMII IAGLSLPSAL 
241:	SLYWVIGNIF MIIQTYFIVV KAPPLEVEQT KQKSSKPNKA