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2.A.9.4.1
Oxa2 (Cox18) YidC homologue (replace E. coli YidC for SecYEG-independent insertion by genetic complementation) (Bloois et al., 2007).

Accession Number:P53239
Protein Name:OXA2
Length:316
Molecular Weight:35650.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate proteins

Cross database links:

Genevestigator: P53239
eggNOG: fuNOG05038
HEGENOM: HBG397443
DIP: DIP-5161N
RefSeq: NP_011576.1   
Entrez Gene ID: 852953   
Pfam: PF02096   
KEGG: sce:YGR062C   

Gene Ontology

GO:0031305 C:integral to mitochondrial inner membrane
GO:0032977 F:membrane insertase activity
GO:0005515 F:protein binding
GO:0032979 P:protein insertion into mitochondrial membra...

References (4)

[1] “Cloning and characterization of COX18, a Saccharomyces cerevisiae PET gene required for the assembly of cytochrome oxidase.”  Souza R.L.et.al.   10809734
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.”  Tettelin H.et.al.   9169869
[3] “Cox18p is required for export of the mitochondrially encoded Saccharomyces cerevisiae Cox2p C-tail and interacts with Pnt1p and Mss2p in the inner membrane.”  Saracco S.A.et.al.   11950926
[4] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLKRLANRQN GFASFSCSSV GLRYGRTNPS TKRSFSLFQS VADTFLTVHE ASHIPWIVLV 
61:	PLTTMTLRTL VTLPFSIWQR RRILKQQELR KLVQPITPII KLRLAAVTNK KSRNAARISS 
121:	NGSFMPLQLQ NAGVLTPEQI TLLAVKETRK RQKKLFKKYN VPLWKNALLP MVQIPLWVTV 
181:	SMGIRTLTET QLIESFYPSW FSALGFSSFD LSSPLVAMPL LAPILVGTLA VLNVELNGRL 
241:	MFSSSLSSQG IKTISRNSTR VQEAMTSILN VSRLGCVVML AMSSQAPFLL SLYWISSQLF 
301:	SLVQNIILNW IYPYQR