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2.A.90.1.1
The STRA6 vitamin A transporter/RBP receptor mediates cellular uptake of Vitamin A (Sun, 2011). Of 668 aas and probably 9 TMSs (Kawaguchi et al. 2015).  Transport is reversible, and is probably mediated by a carrier or group translocation mechanism (Kelly and von Lintig 2015).  Mechanistic features have been discussed (Kawaguchi et al. 2015), and it was concluded that energy-independent facilitated diffusion, from external retinol binding protein (RBP) to internal CRBP-1 or the corresponding CRABP (for retinoic acid) after release of the substrate into the iipid environment of the membrane or an enzyme that forms retinol esters (LRAT) provides the most probable mechanism.

Accession Number:Q0V8E7
Protein Name:STRA6
Length:668
Molecular Weight:73762.00
Species:Bos taurus (Bovine) [9913]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Vitamin A

Cross database links:

eggNOG: maNOG11617
RefSeq: NP_001069198.1   
Entrez Gene ID: 515911   
KEGG: bta:515911   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0004872 F:receptor activity
GO:0006810 P:transport

References (2)

[1] “Characterization of 954 bovine full-CDS cDNA sequences.”  Harhay G.P.et.al.   16305752
[2] “A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A.”  Kawaguchi R.et.al.   17255476

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSTQAAGNQT SSGATDSEDS YDSWYIDEPQ GGQELQPEGL VPSCQPNVPP SLYHTCLAVL 
61:	SILVLFLLAM LVRRRQLWPR CGHGRPGLPS PVDFLTGDRP RTVPAAVFMV LFSSLCLLLP 
121:	TEDPLPFLSL ASPPGRDGEA ETSRGPWKIL ALLYYPALYY PLAACATVRH GAAHLLGSLL 
181:	SWAHLGVQVW QRAECPESPK IYKYYSLLAS LPLLLGLGFL SLWYPVQLVR SFGHGAATGS 
241:	KGLQSSYSEE YLRTLLCQKK LKSSSHTCKR GFASQAWMYF RHSVYIPQRG FRLPLKLVLS 
301:	VTLTGTAIYQ VALLLLVGVV PTIQKVRAGI TTDVSYLLAG FGIVLSEDRQ EVVELVKHHL 
361:	WALEVCYISA LVLSCLLTFL MLVHSLVTHR TNLRALHRGG ALDIGPLTQS PRPSRQAIFC 
421:	WMSFTAYQTA FTCLGLLVQQ ILFFLGTLTL AFLVFMPMLH GRNLLLLHYL KSSWPFWLTL 
481:	ALAVTLQNAA AHWAFLDTHH GRPGLTNRRA LYAATFLLFP VNVLVGTMVA AWRVLLSALY 
541:	NAVHLGRMDL SLLPLRAATL DPGYHTYCNF LRMEASQSHP AATAFCALLL RTQRPKPRAT 
601:	PQDGLRLGEE EEGIQLLQTK DLVAKGAGPR ARQGRARWGL AYTLLHNPAL QAFRKTALPG 
661:	ARPNGAQP