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2.A.90.1.2
Stimulated by retinoic acid gene 6, STRA6 (670 aas; 8-10 TMSs predicted with N- and C-termini outside) (Kawaguchi et al., 2008).  Mechanistic features have been discussed (Kawaguchi et al. 2015), and it was concluded that energy-independent facilitated diffusion, from external holo-retinol binding protein (RBP) to internal CRBP-1 or the corresponding CRABP (for retinoic acid) after release of the substrate into the iipid environment of the membrane or an enzyme that forms retinol esters (LRAT) provides the most probable mechanism.

Accession Number:O70491
Protein Name:STRA6
Length:670
Molecular Weight:73775.00
Species:Mouse [10090]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Vitamin A

Cross database links:

Genevestigator: O70491
HEGENOM: HBG445776
RefSeq: NP_001155947.1    NP_001155948.1    NP_001155951.1    NP_033317.2   
Entrez Gene ID: 20897   
KEGG: mmu:20897   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0004872 F:receptor activity
GO:0006810 P:transport

References (7)

[1] “Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane protein.”  Bouillet P.et.al.   9203140
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types.”  Taneja R.et.al.   7644503
[4] “Restricted expression of a novel retinoic acid responsive gene during limb bud dorsoventral patterning and endochondral ossification.”  Chazaud C.et.al.   8792610
[5] “Differential expression of retinoic acid-inducible (Stra) genes during mouse placentation.”  Sapin V.et.al.   10727869
[6] “Overexpression of the retinoic acid-responsive gene Stra6 in human cancers and its synergistic induction by Wnt-1 and retinoic acid.”  Szeto W.et.al.   11358845
[7] “Synergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profiling.”  Tice D.A.et.al.   11832495

External Searches:

  • Search: DB with
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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MESQASENGS QTSSGVTDDY SSWYIEEPLG AEEVQPEGVI PLCQLTAPPA LLHACLASLS 
61:	FLVLLLLALL VRRRRLWPRC GHRGLGLPSP VDFLAGDLSW TVPAAVFVVL FSNLCLLLPD 
121:	ENPLPFLNLT AASSPDGEME TSRGPWKLLA LLYYPALYYP LAACASAGHQ AAFLLGTVLS 
181:	WAHFGVQVWQ KAECPQDPKI YKHYSLLASL PLLLGLGFLS LWYPVQLVQS LRHRTGAGSQ 
241:	GLQTSYSEKY LRTLLCPKKL DSCSHPASKR SLLSRAWAFS HHSIYTPQPG FRLPLKLVIS 
301:	ATLTGTATYQ VALLLLVSVV PTVQKVRAGI NTDVSYLLAG FGIVLSEDRQ EVVELVKHHL 
361:	WTVEACYISA LVLSCASTFL LLIRSLRTHR ANLQALHRGA ALDLDPPLQS IHPSRQAIVS 
421:	WMSFCAYQTA FSCLGLLVQQ VIFFLGTTSL AFLVFVPLLH GRNLLLLRSL ESTWPFWLTV 
481:	ALAVILQNIA ANWIFLRTHH GYPELTNRRM LCVATFLLFP INMLVGAIMA VWRVLISSLY 
541:	NTVHLGQMDL SLLPQRAASL DPGYHTYQNF LRIEASQSHP GVIAFCALLL HAPSPQPRPP 
601:	LAPQDSLRPA EEEEGMQLLQ TKDLMAKGAG HKGSQSRARW GLAYTLLHNP SLQAFRKAAL 
661:	TSAKANGTQP