TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.90.1.3
STRA6 of 667 aas and 9 - 12 putative TMSs (Zhong et al. 2013).  Mechanistic features have been discussed (Kawaguchi et al. 2015), and it was concluded that energy-independent facilitated diffusion, from external holo-retinol binding protein (RBP) to internal CRBP-1 or the corresponding CRABP (for retinoic acid) after release of the substrate into the iipid environment of the membrane or an enzyme that forms retinol esters (LRAT) provides the most probable mechanism of transport.  STRA6 binds RBP with a 1:1 stoichiometry (Breen et al. 2015).

Accession Number:Q9BX79
Protein Name:Stimulated by retinoic acid gene 6 protein homolog
Length:667
Molecular Weight:73503.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Vitamin A

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSSQPAGNQT SPGATEDYSY GSWYIDEPQG GEELQPEGEV PSCHTSIPPG LYHACLASLS 
61:	ILVLLLLAML VRRRQLWPDC VRGRPGLPSP VDFLAGDRPR AVPAAVFMVL LSSLCLLLPD 
121:	EDALPFLTLA SAPSQDGKTE APRGAWKILG LFYYAALYYP LAACATAGHT AAHLLGSTLS 
181:	WAHLGVQVWQ RAECPQVPKI YKYYSLLASL PLLLGLGFLS LWYPVQLVRS FSRRTGAGSK 
241:	GLQSSYSEEY LRNLLCRKKL GSSYHTSKHG FLSWARVCLR HCIYTPQPGF HLPLKLVLSA 
301:	TLTGTAIYQV ALLLLVGVVP TIQKVRAGVT TDVSYLLAGF GIVLSEDKQE VVELVKHHLW 
361:	ALEVCYISAL VLSCLLTFLV LMRSLVTHRT NLRALHRGAA LDLSPLHRSP HPSRQAIFCW 
421:	MSFSAYQTAF ICLGLLVQQI IFFLGTTALA FLVLMPVLHG RNLLLFRSLE SSWPFWLTLA 
481:	LAVILQNMAA HWVFLETHDG HPQLTNRRVL YAATFLLFPL NVLVGAMVAT WRVLLSALYN 
541:	AIHLGQMDLS LLPPRAATLD PGYYTYRNFL KIEVSQSHPA MTAFCSLLLQ AQSLLPRTMA 
601:	APQDSLRPGE EDEGMQLLQT KDSMAKGARP GASRGRARWG LAYTLLHNPT LQVFRKTALL 
661:	GANGAQP