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2.A.90.1.4
STRA6 of 670 aas, mediates cellular uptake of vitamin A by recognizing RBP-retinol to trigger release and internalization of retinol. Chen et al. 2016 presented the structure of zebrafish STRA6, determined to 3.9-angstrom resolution by single-particle cryo-electron microscopy. STRA6 has one intramembrane and nine transmembrane helices in an intricate dimeric assembly. Calmodulin is bound tightly to STRA6 in a noncanonical arrangement. Residues involved with RBP binding map to an arch-like structure that covers a deep lipophilic cleft. This cleft is open to the membrane, suggesting a possible mode for internalization of retinol through direct diffusion into the lipid bilayer.

Accession Number:Q1ECX5
Protein Name:Zgc:136689
Length:670
Molecular Weight:75411.00
Species:Danio rerio (Zebrafish) [7955]
Number of TMSs:13
Substrate Vitamin A

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSAETVNNYD YSDWYENAAP TKAPVEVIPP CDPTADEGLF HICIAAISLV VMLVLAILAR 
61:	RQKLSDNQRG LTGLLSPVNF LDHTQHKGLA VAVYGVLFCK LVGMVLSHHP LPFTKEVANK 
121:	EFWMILALLY YPALYYPLLA CGTLHNKVGY VLGSLLSWTH FGILVWQKVD CPKTPQIYKY 
181:	YALFGSLPQI ACLAFLSFQY PLLLFKGLQN TETANASEDL SSSYYRDYVK KILKKKKPTK 
241:	ISSSTSKPKL FDRLRDAVKS YIYTPEDVFR FPLKLAISVV VAFIALYQMA LLLISGVLPT 
301:	LHIVRRGVDE NIAFLLAGFN IILSNDRQEV VRIVVYYLWC VEICYVSAVT LSCLVNLLML 
361:	MRSMVLHRSN LKGLYRGDSL NVFNCHRSIR PSRPALVCWM GFTSYQAAFL CLGMAIQTLV 
421:	FFICILFAVF LIIIPILWGT NLMLFHIIGN LWPFWLTLVL AALIQHVASR FLFIRKDGGT 
481:	RDLNNRGSLF LLSYILFLVN VMIGVVLGIW RVVITALFNI VHLGRLDISL LNRNVEAFDP 
541:	GYRCYSHYLK IEVSQSHPVM KAFCGLLLQS SGQDGLSAQR IRDAEEGIQL VQQEKKQNKV 
601:	SNAKRARAHW QLLYTLVNNP SLVGSRKHFQ CQSSESFING ALSRTSKEGS KKDGSVKEPS 
661:	KEAESAAASN