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2.A.95.1.1
MarC or YdeB of 221 aas and 6 TMSs. The role of MarC in MDR is controversial (McDermott et al., 2008).  It may function in conjunction with YdeA, an MFS pump (TC# 2.A.1.2.15) (Zakataeva et al. 2006).

Accession Number:P0AEY1
Protein Name:Multiple antibiotic resistance protein MarC aka B1529
Length:221
Molecular Weight:23617.00
Species:Escherichia coli [83333]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate antibiotics

Cross database links:

Genevestigator: P0AEY1
EchoBASE: EB1593
EcoGene: EG11637
eggNOG: COG2095
HEGENOM: HBG731519
RefSeq: AP_002150.1    NP_416046.1   
Entrez Gene ID: 947132   
Pfam: PF01914   
BioCyc: EcoCyc:EG11637-MONOMER    ECOL168927:B1529-MONOMER   
KEGG: ecj:JW1522    eco:b1529   

Gene Ontology

GO:0005887 C:integral to plasma membrane

References (7)

[1] “Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli.”  Cohen S.P.et.al.   8383113
[2] “A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map.”  Aiba H.et.al.   9097039
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Rapid topology mapping of Escherichia coli inner-membrane proteins by prediction and PhoA/GFP fusion analysis.”  Drew D.et.al.   11867724
[6] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
[7] “The marC gene of Escherichia coli is not involved in multiple antibiotic resistance.”  McDermott P.F.et.al.   17954692

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLDLFKAIGL GLVVLLPLAN PLTTVALFLG LAGNMNSAER NRQSLMASVY VFAIMMVAYY 
61:	AGQLVMDTFG ISIPGLRIAG GLIVAFIGFR MLFPQQKAID SPEAKSKSEE LEDEPSANIA 
121:	FVPLAMPSTA GPGTIAMIIS SASTVRQSST FADWVLMVAP PLIFFLVAVI LWGSLRSSGA 
181:	IMRLVGKGGI EAISRLMGFL LVCMGVQFII NGILEIIKTY H