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2.A.96.1.4
The acetate permease, Ady2, required for normal sporulation; phosphorylated in mitochondria (Paiva et al., 2004)

Accession Number:P25613
Protein Name:Uncharacterized protein YCR010C
Length:283
Molecular Weight:30726.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Acetate

Cross database links:

Genevestigator: P25613
eggNOG: fuNOG05598
HEGENOM: HBG736287
DIP: DIP-7894N
RefSeq: NP_009936.1   
Entrez Gene ID: 850368   
Pfam: PF01184   
KEGG: sce:YCR010C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005739 C:mitochondrion
GO:0005886 C:plasma membrane
GO:0001950 C:plasma membrane enriched fraction
GO:0005774 C:vacuolar membrane
GO:0015123 F:acetate transmembrane transporter activity
GO:0008519 F:ammonium transmembrane transporter activity
GO:0006846 P:acetate transport
GO:0015696 P:ammonium transport
GO:0007126 P:meiosis
GO:0019740 P:nitrogen utilization
GO:0055085 P:transmembrane transport

References (10)

[1] “The complete sequence of a 10.8 kb segment distal of SUF2 on the right arm of chromosome III from Saccharomyces cerevisiae reveals seven open reading frames including the RVS161, ADP1 and PGK genes.”  Skala J.et.al.   1626432
[2] “The complete DNA sequence of yeast chromosome III.”  Oliver S.G.et.al.   1574125
[3] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[4] “Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase.”  Reinders J.et.al.   17761666
[5] “A screen for genes required for meiosis and spore formation based on whole-genome expression.”  Rabitsch K.P.et.al.   11470404
[6] “Ammonia pulses and metabolic oscillations guide yeast colony development.”  Palkova Z.et.al.   12429834
[7] “Ady2p is essential for the acetate permease activity in the yeast Saccharomyces cerevisiae.”  Paiva S.et.al.   14968426
[8] “Spore number control and breeding in Saccharomyces cerevisiae: a key role for a self-organizing system.”  Taxis C.et.al.   16286509
[9] “Association of putative ammonium exporters Ato with detergent-resistant compartments of plasma membrane during yeast colony development: pH affects Ato1p localisation in patches.”  Ricicova M.et.al.   17395151
[10] “Mutations at different sites in members of the Gpr1/Fun34/YaaH protein family cause hypersensitivity to acetic acid in Saccharomyces cerevisiae as well as in Yarrowia lipolytica.”  Gentsch M.et.al.   17233767

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSDKEQTSGN TDLENAPAGY YSSHDNDVNG VAEDERPSHD SLGKIYTGGD NNEYIYIGRQ 
61:	KFLKSDLYQA FGGTLNPGLA PAPVHKFANP APLGLSAFAL TTFVLSMFNA RAQGITVPNV 
121:	VVGCAMFYGG LVQLIAGIWE IALENTFGGT ALCSYGGFWL SFAAIYIPWF GILEAYEDNE 
181:	SDLNNALGFY LLGWAIFTFG LTVCTMKSTV MFFLLFFLLA LTFLLLSIGH FANRLGVTRA 
241:	GGVLGVVVAF IAWYNAYAGV ATKQNSYVLA RPFPLPSTER VIF