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TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.96.1.1









Acetate/succinate transporter, SatP or YaaH (Sá-Pessoa et al. 2013).  It is specific for acetate (a monocarboxylate) and for succinate (a dicarboxylate), with affinity constants at pH 6.0 of 1.24 ± 0.13 mM for acetate and 1.18 ± 0.10 mM for succinate. In glucose grown-cells, the ΔyaaH mutant is compromised for the uptake of both labelled acetic and succinic acids. YaaH, together with ActP, previously described as an acetate transporter, affect the use of acetic acid as sole carbon and energy source. Both genes have to be deleted simultaneously to abolish acetate transport. The uptake of acetate and succinate was restored when yaaH was expressed in trans in ΔyaaH ΔactP cells. YaaH amino acid residues Leu131 and Ala164 are important for the enhanced ability to transport lactate (Sá-Pessoa et al. 2013). The 3-d structure has been determined to 2.8 Å resolution showing that it is a hexamer with each protomer having a central pore surrounded by 6 TMSs (Sun et al. 2018) (see family description for more details).

Bacteria
Proteobacteria
SatP (YaaH) of E. coli (P0AC98)
*2.A.96.1.2









Gpr1/YarL1 glyoxylate pathway regulator.  Plays a role in acetate sensitivity (Augstein et al. 2003; Gentsch et al. 2007Gentsch et al. 2007).  Probably an acetate transporter.

Eukaryota
Fungi
Gpr1 of Yarrowia lipolytica (P41943)
*2.A.96.1.3









The acetate permease, AcpA (Robellet et al., 2008). (induced by acetate, ethanol and ethyl acetate). This systems and its orthologs in fungi have been reviewed (Guo et al. 2018).

Eukaryota
Fungi
AcpA of Emericella (Aspergillus) nidulans (Q5B2K4)
*2.A.96.1.4









The acetate permease, Ady2, required for normal sporulation; phosphorylated in mitochondria (Paiva et al., 2004)
Eukaryota
Fungi
Ady2 of Saccharomyces cerevisiae (P25613)
*2.A.96.1.5









The ammonium exporter (ammonium outward transporter 2), Ato2 or Fun34 (Guaragnella and Butow, 2003; Ricicová et al., 2007)

Eukaryota
Fungi
Ato3 of Saccharomyces cerevisiae (Q12359)
*2.A.96.1.6









Meiotically up-regulated gene 86 protein, Mug86

Eukaryota
Fungi
Mug86 of Schizosaccharomyces pombe
*2.A.96.1.7









Ammonia transport outward protein 2, ATO2

Eukaryota
Fungi
ATO2 of Saccharomyces cerevisiae
*2.A.96.1.8









Uncharacterized protein of 182 aas and 6 TMSs.

Bacteria
Tenericutes
UP of Acholeplasma modicum
*2.A.96.1.9









Uncharacterized protein of 200 aas and 6 TMSs.

Archaea
Euryarchaeota
UP of Methanosarcina soligelidi
*2.A.96.1.10









GPR1/FUN34/YaaH family of 298 aas and 6 TMSs.

Eukaryota
Kinetoplastida
GPR1 protein of Angomonas deanei
*2.A.96.2.1









Ethanol-induced protein AlcS (6 TMSs.  May be distantly related to the second half (TMSs 7-12)) of APC family member, 3.A.3.3.4. This subfamily is absent from yeast and bacteria (Flipphi et al., 2006).

Eukaryota
Fungi
AlcS of Emericella (Aspergillus) nidulans (Q460G9)
*2.A.96.2.2









GPR1 protein of 259 aas and 6 TMSs.

Eukaryota
Fungi
GPR1 protein of Lentinula edodes
*2.A.96.2.3









Uncharacterized protein of 309 aas with a 100 residue hydrophilic N-terminus, and a 6 TMS C-terminal region.

Eukaryota
Fungi
UP of Mycosphaerella eumusae (Pseudocercospora eumusae)