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2.A.97.1.3
The mitochondrial LetM1 Ca2+/H+ antiporter (Jiang et al., 2009).

Accession Number:P91927
Protein Name:LETM1 and EF-hand domain-containing protein anon-60Da, mitochondrial
Length:1013
Molecular Weight:113580.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Mitochondrion membrane1 / Single-pass membrane protein2
Substrate Ca2+

Cross database links:

eggNOG: inNOG08808
DIP: DIP-23753N
RefSeq: NP_611922.1    NP_726453.1    NP_726454.1   
Entrez Gene ID: 37912   
Pfam: PF07766   
BioCyc: DMEL-XXX-02:DMEL-XXX-02-006483-MONOMER    DMEL-XXX-02:DMEL-XXX-02-006484-MONOMER    DMEL-XXX-02:DMEL-XXX-02-006485-MONOMER   
KEGG: dme:Dmel_CG4589   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0031966 C:mitochondrial membrane
GO:0005509 F:calcium ion binding

References (4)

[1] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[2] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[3] “A Drosophila full-length cDNA resource.”  Stapleton M.et.al.   12537569
[4] “Identification of nuclear genes encoding mitochondrial proteins: isolation of a collection of D. melanogaster cDNAs homologous to sequences in the Human Gene Index database.”  Caggese C.et.al.   10071211

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MNALLRHKGR NLRTSHLAQN VYKRFLKSNC CACSSVNVTD EPAKEDELPR RSASTSVLEL 
61:	SRSLGTYRRF QPHANYGYDY SGYGFRHLHT SRTLLETSSS KIDATVKKLK NQQKEKVEEI 
121:	MKEVANGQAA AVRASSAATA TASSEKGQNA SATAGSTSAT ASTTSLAKTA DKSVAKPKKP 
181:	LRTRIWDELV HYYHGFRLLF IDVAICSKLL WRVLNGKTLT RRENKQLQRT TSDLFRLIPF 
241:	SVFIIVPFME LLLPLFIKFF PGMLPSTFQT STDRQEKLRQ SLSVRLEVAK FLQQTLDQMP 
301:	VQHKEHSSEE AKQFEAFFTK IRNPTEPVSN DEIIKFAKRF DDEITLDSLS REQLAALCRV 
361:	LELNTIGTTT LLRFQLRLKL RSLATDDRVI AREGVDSLDL LELQQACKAR GMRAYGLTEE 
421:	RLRFQLKEWI DLSLNEQVPP TLLLLSRTML ISDDSITTDK LKETIRVLPD AVGAHTRHAI 
481:	GESEGKVDNK TKIEIIKEEE RKIREEREEE REETIAKRSA IKEEIPAPYV FAEKLSGSQD 
541:	LLDHKEQSSV SETDKGISST DVQLLSEALK TLSSDKQLVV EKETIKELKE ELADYKEDVE 
601:	ELREVRQVVK EPVRESRAAK LLYNRVNKMI SQLDNVLNDL EARQHQIKQA ESSDYAASSP 
661:	TVEPQQMVHI DELVATIRRM KEASDEERFK VVGDLLVKLD ADKDGVISVN EITKAVQSID 
721:	REATNIDKKQ LEEFTELLSK LASRRRHEEI VHIDDLMNNI KVLKETSDEA RLKHIEAVLE 
781:	KFDADKDGVV TVNDIRKVLE SIGRDNIKLS DKAIEELISL LDKEQVLQAE QKIEKAIAKS 
841:	MKEAEKLKSE VDKADKDLSK LVNDIHDSAK EIQDIANEMR DKEETVPDKA KELKAEPAFK 
901:	DTAKTLKDNA KDLDDLAKDP KSDPKSPTKA STGSGPAGLS GGGPSSGSSG IATGSTTESA 
961:	LREAAERQME KILPSTDIGL PPTIQTPSQP PTSKKATATA STLSTTITAK KLL