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2.A.97.1.4
The yeast Mdm38 (LETM1; YLH47) is a homologue of the human LETM1, the candidate gene for seizures in Wolf-Hirchhorn syndrome. They may be K+/H+ antiporters (Zotova et al., 2010).

Accession Number:Q06493
Protein Name:LETM1 domain-containing protein YLH47, mitochondrial
Length:454
Molecular Weight:52174.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Single-pass membrane protein2
Substrate K+, H+

Cross database links:

Genevestigator: Q06493
eggNOG: fuNOG07700
HEGENOM: HBG395478
DIP: DIP-5345N
Pfam: PF07766   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0006813 P:potassium ion transport
GO:0051204 P:protein insertion into mitochondrial membrane
GO:0015992 P:proton transport

References (6)

[1] “A multitude of suppressors of group II intron-splicing defects in yeast.”  Waldherr M.et.al.   8252639
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.”  Bussey H.et.al.   9169875
[3] “Global analysis of protein localization in budding yeast.”  Huh W.-K.et.al.   14562095
[4] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[5] “The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome.”  Nowikovsky K.et.al.   15138253
[6] “Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery.”  Frazier A.E.et.al.   16476776

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLKYRSLPIK RAIHHPAPGI TPISPRIMVS RLRVIPSFNL KFNRWNSSVP ESSKKELKTT 
61:	DGNQESASKV SPVKEKEKVP FKVKMQKALR HYWDGSKLLG LEIKISSKLL MKSAAGYPLT 
121:	RRENLQLKRT TQDIVRLVPF AAFLIIPFAE LLLPFALKLF PNLLPSTYES SKKRENKLEN 
181:	LRNTRKLMSE IIKNNKSHFK PNNISEEQKA LFNRFYTHVR ATGVPESRQQ LIEVARLFTD 
241:	DTVLDNVTRP YLIALAKYMN LQPFGTDVML RYRIRYKMLE LKKDDLSIYY EDAEQLSLSE 
301:	LKTACASRGI RSVDVEPSVL YSNLRLWLNM RLKDKIPSTL LIMATAYNYG NVQSKESLYD 
361:	ALCDVLIGIP DELYHEVKVN VVKEDEASAK QKLKQLREQE EIMKEEEQQE ENAIVSVKDE 
421:	LSLDDQDKNI DAAAPDVKPH DTKPIGEAAA IKEK