TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.99.1.1









The highly specific Ni2+ uptake porter, HupE of 191 aas and 6 or 7 putative TMSs (Brito et al., 2010; Albareda et al. 2015).  HupE is a medium-affinity and low-capacity transporter - its periplasmic region, 22HVGLHADGTLAGLN35, binds Ni2+ with much higher affinity than the transmembrane 36HPFSGLDH43 one, which transports the metal into the cell. The specificity of the transmembrane region is similar to that of the periplasmic one and to that of the full-length HupEAlbareda et al. 2015).  HupE is a medium-affinity and low-capacity transporter - its periplasmic region, 22HVGLHADGTLAGLN35, binds Ni2+ with much higher affinity than the transmembrane 36HPFSGLDH43 one, which transports the metal into the cell. The specificity of the transmembrane region is similar to that of the periplasmic one and to that of the full-length HupE (Rowińska-Żyrek 2017).

Bacteria
Proteobacteria
HupE of Rhizobium leguminosarum (P27650)
*2.A.99.1.2









The 6TMS Ni2+ uptake porter, HupE2 (Brito et al., 2010).

Bacteria
Proteobacteria
HupE2 of Rhizobium leguminosarum (Q1M8G8)
*2.A.99.1.3









Urease accessory protein, UreJ

Bacteria
Proteobacteria
UreJ of Mesorhizobium loti (Q98CY5)