2.B.29 The Anionophoric Marine Alkaloid Tambjamine (AMAT) Family
Soto-Cerrato et al. 2015 used two potent anionophore analogues of tambjamines to study the effects induced by these compounds at the cellular level. They showed that active anionophores, capable of facilitating the transmembrane transport of chloride and bicarbonate in model phospholipid liposomes, induce acidification of the cytosol and hyperpolarization of plasma cell membranes, the combined effects of which can be used against cancer stem cells (Soto-Cerrato et al. 2015).