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2.B.39.  The Tambjamine Derivative Anion Channel (TD-AC) Family 

The transmembrane anion transport activity of a series of synthetic molecules, based on the structure of tambjamine alkaloids, can be tuned by varying the lipophilicity of the receptor, with carriers within a certain log P value (n-octanol/water partition coefficient) range performing best (Saggiomo et al. 2012). These compounds transport Cl-, OH- and HCO3-, probably using an antiport mechanism; see Figure 10 in Gale et al. 2017 for the structures of effective derivatives.

References associated with 2.B.39 family:

Gale, P.A., J.T. Davis, and R. Quesada. (2017). Anion transport and supramolecular medicinal chemistry. Chem Soc Rev 46: 2497-2519. 28379234
Saggiomo, V., S. Otto, I. Marques, V. FĂ©lix, T. Torroba, and R. Quesada. (2012). The role of lipophilicity in transmembrane anion transport. Chem Commun (Camb) 48: 5274-5276. 22531689