2.B.39. The Tambjamine Derivative Anion Channel (TD-AC) Family
The transmembrane anion transport activity of a series of synthetic molecules, based on the structure of tambjamine alkaloids, can be tuned by varying the lipophilicity of the receptor, with carriers within a certain log P value (n-octanol/water partition coefficient) range performing best (Saggiomo et al. 2012). These compounds transport Cl-, OH- and HCO3-, probably using an antiport mechanism; see Figure 10 in Gale et al. 2017 for the structures of effective derivatives.