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2.B.40.  The Monoacylglycerol Anion Carrier (MAG-AC) Family 

Bahmanjah et al. 2012 showed that amphiphilic natural products, monoacylglycerols (see Fig 29 in Gale et al. 2017), function as transmembrane Cl-/NO3- anion exchange transporters. The 1,2-diol group proved to be crucial for transport function since diacylglycerol and triacylglycerol analogs were not anion transporters. Adding another hydrogen bond donor to the glycerol head-group and perfluorination of the acyl tail gave synthetic analogs with improved Cl- membrane transport properties with 20-fold better Cl-/NO3- antiport activity than the parental compound.

References associated with 2.B.40 family:

Bahmanjah, S., N. Zhang, and J.T. Davis. (2012). Monoacylglycerols as transmembrane Cl- anion transporters. Chem Commun (Camb) 48: 4432-4434. 22457876
Gale, P.A., J.T. Davis, and R. Quesada. (2017). Anion transport and supramolecular medicinal chemistry. Chem Soc Rev 46: 2497-2519. 28379234