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3.A.1.109.2
Cyclolysin exporter, CyaB (Glaser et al., 1988) (Possesses an N-terminal lysosomal sorting signal within the amino-terminal transmembrane domain; Kamakura et al., 2008).

Accession Number:P18770
Protein Name:CyaB
Length:712
Molecular Weight:77646.00
Species:Bordetella pertussis [520]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Cyclolysin

Cross database links:

HEGENOM: HBG758042
RefSeq: NP_879579.1   
Entrez Gene ID: 2664566   
Pfam: PF00664    PF00005    PF03412   
BioCyc: BPER257313:BP0761-MONOMER   
KEGG: bpe:BP0761   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0030256 C:type I protein secretion system complex
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0008234 F:cysteine-type peptidase activity
GO:0008565 F:protein transporter activity
GO:0019835 P:cytolysis
GO:0019836 P:hemolysis by symbiont of host erythrocytes
GO:0030253 P:protein secretion by the type I secretion s...
GO:0006508 P:proteolysis
GO:0055085 P:transmembrane transport

References (2)

[1] “Secretion of cyclolysin, the calmodulin-sensitive adenylate cyclase-haemolysin bifunctional protein of Bordetella pertussis.”  Glaser P.et.al.   2905265
[2] “Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.”  Parkhill J.et.al.   12910271

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTSPVAQCAS VPDSGLLCLV MLARYHGLAA DPEQLRHEFA EQAFCSETIQ LAARRVGLKV 
61:	RRHRPAPARL PRAPLPAIAL DRQGGYFVLA RFEPGADQAV LIQRPGQAPA RLGQAEFEAL 
121:	WAGELLLCAC AASPTQALAR FDFSWFIPAL VKHRHLIGEV LLISLVLQFI ALLTPLFFQV 
181:	VMDKVLVNNA METLNVIAVG FLAAILFEAL LTGIRTYLFA HTSSKLDVEL GARLYAHLLR 
241:	LPLAYFQARR VGDSVARVRE LEHIRAFLTG NAVTVLLDVV FSVVFIAVMF FYSVKLTLVV 
301:	LAALPCYFLL SLVLTPVLRR RLDVKFNRGA ENQAFLVETV SGIDTVKSLA VEPQWQRNWD 
361:	RQLAGYVAAG LSVANVAMLA NTGVTLISRL VALGVLWVGA TEVVAQRMTV GELVAFNMLS 
421:	GHVTQPVIRL AQLWNDFQQT GVSMQRLGDI LNCRTEVAGD KAQLPALRGS IELDRVSFRY 
481:	RPDAADALRN VSLRIAPGEV VGVVGRSGSG KSTLTRLIQR MFVADRGRVL IDGHDIGIVD 
541:	SASLRRQLGV VLQESTLFNR SVRDNIALTR PGASMHEVVA AARLAGAHEF ICQLPEGYDT 
601:	MLGENGVGLS GGQRQRIGIA RALIHRPRVL ILDEATSALD YESEHIIQRN MRDICDGRTV 
661:	IIIAHRLSAV RCADRIVVME GGEVAECGSH ETLLAAGGLY ARLQALQAGE AG