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3.A.1.111.1
Hemolysin/bacteriocin (cytolysin) exporter with associated proteolytic activity

Accession Number:Q57403
Protein Name:CylT aka CylB aka ClyB
Length:714
Molecular Weight:82052.00
Species:Enterococcus faecalis (Streptococcus faecalis) [2520]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Hemolysins, Bacteriocins

Cross database links:

Pfam: PF00664    PF00005    PF03412   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0008233 F:peptidase activity
GO:0006508 P:proteolysis
GO:0055085 P:transmembrane transport

References (2)

[1] “Genetic structure of the Enterococcus faecalis plasmid pAD1-encoded cytolytic toxin system and its relationship to lantibiotic determinants.”  Gilmore M.S.et.al.   7961506
[2] “An HlyB-type function is required for expression of the Enterococcus faecalis hemolysin/bacteriocin.”  Gilmore M.S.et.al.   2123826

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MKRLKYVAQG EHSECALACI TMLLNYYGNQ STLVELREKY GVPKGGLTIK NIRTVFDEYG 
61:	FDVSTFKSSF SNYLDLPTPV ISYWNNQHFV VIEKIKKKKV LILDPASNKR WIDISEFKKN 
121:	FSNILIYAHK KKTKKEGKRK QFFLKSFIFT KFKRYFFSLI ILSFVSQLLL LLIPIATKYS 
181:	IDNIRSFQEI PTYVLLLILT SFFSVLYVVQ YLKSSVVAEF QYEFDFKLMF SYIDKLFSMP 
241:	LMYFSNRSTG ELVFRANLNI YIRQILSQKV ITTLIDSLFL GIYLFLMVNY SILLTIIALV 
301:	LISLIAFLSI INSHTIKRFV DKEIMEQGNV QRIITEAIEG IETIKSANAK KSFLLNWKNM 
361:	FTSQLLITKN KNRYIAIFGI LPEIIQSVMP ALFLIIGIKL IINNSLSLGS LIGFVSIVTM 
421:	VMKPILSLVS SYNDFLLLNV YFQKLSEVLT YEEKNDFNNK KGNVGKEEFI YRVNNVYYTI 
481:	SVFEKNILNG ISFDIRKGDK VAIVGRSGSG KSTLLKLLAG LLQPSNGEIL YEGYPLSNNS 
541:	NNRRNIFYVN QNAHIFNETI EKNISLEFKP NSSINEKKRL KGSMSKSKMD EVLLGIPQYE 
601:	KTIVSENGSN FSGGQRQKIA LARAFYSNVN TLLLDEPTSA MDNISEFEVF SNLLDEKRTV 
661:	ITVAHRISTV KNFDKIILMD NGEIVCIGKH EDLIENSELY RSLYYKKQQF GGTK