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3.A.1.112.1
Competence factor (CSF; a heptadecapeptide) exporter of 717 aas.  The transporter is fused to an N-terminal peptidase  domain and functions with an MFP  accessory protein, ComB (TC# 8.A.1.4.2) (Ishii et al. 2006). 

Accession Number:Q03727
Protein Name:ComA aka SP0042
Length:717
Molecular Weight:80404.00
Species:Streptococcus pneumoniae [1313]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Competence Factor

Cross database links:

HEGENOM: HBG758042
RefSeq: NP_344591.1   
Entrez Gene ID: 929792   
Pfam: PF00664    PF00005    PF03412   
KEGG: spn:SP_0042   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0008234 F:cysteine-type peptidase activity
GO:0019534 F:toxin transporter activity
GO:0030420 P:establishment of competence for transformation
GO:0006508 P:proteolysis
GO:0055085 P:transmembrane transport

References (3)

[1] “Genetic transformation in Streptococcus pneumoniae: nucleotide sequence analysis shows comA, a gene required for competence induction, to be a member of the bacterial ATP-dependent transport protein family.”  Hui F.M.et.al.   1987129
[2] “Complete genome sequence of a virulent isolate of Streptococcus pneumoniae.”  Tettelin H.et.al.   11463916
[3] “Competence for genetic transformation in Streptococcus pneumoniae: organization of a regulatory locus with homology to two lactococcin A secretion genes.”  Hui F.M.et.al.   7883181

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKFGKRHYRP QVDQMDCGVA SLAMVFGYYG SYYFLAHLRE LAKTTMDGTT ALGLVKVAEE 
61:	IGFETRAIKA DMTLFDLPDL TFPFVAHVLK EGKLLHYYVV TGQDKDSIHI ADPDPGVKLT 
121:	KLPRERFEEE WTGVTLFMAP SPDYKPHKEQ KNGLLSFIPI LVKQRGLIAN IVLATLLVTV 
181:	INIVGSYYLQ SIIDTYVPDQ MRSTLGIISI GLVIVYIFQQ ILSYAQEYLL LVLGQRLSID 
241:	VILSYIKHVF HLPMSFFATR RTGEIVSRFT DANSIIDALA STILSIFLDV STVVIISLVL 
301:	FSQNTNLFFM TLLALPIYTV IIFAFMKPFE KMNRDTMEAN AVLSSSIIED INGIETIKSL 
361:	TSESQRYQKI DKEFVDYLKK SFTYSRAESQ QKALKKVAHL LLNVGILWMG AVLVMDGKMS 
421:	LGQLITYNTL LVYFTNPLEN IINLQTKLQT AQVANNRLNE VYLVASEFEE KKTVEDLSLM 
481:	KGDMTFKQVH YKYGYGRDVL SDINLTVPQG SKVAFVGISG SGKTTLAKMM VNFYDPSQGE 
541:	ISLGSVNLNQ IDKKALRQYI NYLSQQPYVF NGTILENLLL GAKEGTTQED ILRAVELAEI 
601:	REDIERMPLN YQTELTSDGA GISGGQRQRI ALARALLTDA PVLILDEATS SLDILTEKRI 
661:	VDNLIALDKT LIFIAHRLTI AERTEKVVVL DQGKIVEEGK HADLLAQGGF YAHLVNS