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3.A.1.117.1
The multidrug exporter, LmrA (can also substitute for MsbA [TC #3.A.1.106.1] to export lipid A; Reuter et al., 2003).  A structural model has been presented (Federici et al. 2007). Hoechst 33342 is a substrate (van den Berg and van Saparoea et al. 2005).

Accession Number:P97046
Protein Name:LmrA
Length:590
Molecular Weight:64617.00
Species:Lactococcus lactis [416870]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate drugs

Cross database links:

eggNOG: COG1132
HEGENOM: HBG758042
RefSeq: YP_001033128.1   
Entrez Gene ID: 4797383   
Pfam: PF00664    PF00005   
KEGG: llm:llmg_1856   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0008559 F:xenobiotic-transporting ATPase activity
GO:0046677 P:response to antibiotic
GO:0055085 P:transmembrane transport

References (2)

[1] “Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.”  van Veen H.W.et.al.   8855237
[2] “The complete genome sequence of the lactic acid bacterial paradigm Lactococcus lactis subsp. cremoris MG1363.”  Wegmann U.et.al.   17307855

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MERGPQMANR IEGKAVDKTS IKHFVKLIRA AKPRYLFFVI GIVAGIIGTL IQLQVPKMVQ 
61:	PLINSFGHGV NGGKVALVIA LYIGSAAVSA IAAIVLGIFG ESVVKNLRTR VWDKMIHLPV 
121:	KYFDEVKTGE MSSRLANDTT QVKNLIANSI PQAFTSILLL VGSIIFMLQM QWRLTLAMII 
181:	AVPIVMLIMF PIMTFGQKIG WTRQDSLANF QGIASESLSE IRLVKSSNAE KQASKKAEND 
241:	VNALYKIGVK EAVFDGLMSP VMMLSMMLMI FGLLAYGIYL ISTGVMSLGT LLGMMMYLMN 
301:	LIGVVPTVAT FFTELAKASG STGRLTELLD EEQEVLHQGD SLDLEGKTLS AHHVDFAYDD 
361:	SEQILHDISF EAQPNSIIAF AGPSGGGKST IFSLLERFYQ PTAGEITIGG QPIDSVSLEN 
421:	WRSQIGFVSQ DSAIMAGTIR ENLTYGLEGN FTDEDLWQVL DLAFARSFVE NMPDQLNTEV 
481:	GERGVKISGG QRQRLAIARA FLRNPKILML DEATASLDSE SESMVQRALD SLMKGRTTLV 
541:	IAHRLSTIVD ADKIYFIEKG EITGSGKHNE LVATHPLYAK YVSEQLTVGQ