TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.1.117.2
Hop resistance protein, HorA. Reconstitution in phosphatidyl ethanolamine bilayers resulted in normal activity, but reconstitution in phosphatidyl choline resulted in uncoupling of ATP hydrolysis from transport and a change in the orientations of the TMSs (Gustot et al. 2010).

Accession Number:O32748
Protein Name:HorA
Length:583
Molecular Weight:64208.00
Species:Lactobacillus brevis [1580]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Hop compounds

Cross database links:

Pfam: PF00664    PF00005   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0055085 P:transmembrane transport

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MQAQSKNNTK FNFKTFMGLI NRIHPRYWQL LLGFFLGVVA TAMQLMVPGI AKGIINSIGH 
61:	SMDVGLIVAV ILLFVSSTII GAFSGSILGF FGEDVVYKLR TTLWDKILTL PVGYFDQTKS 
121:	GEITSRLVND STQVKELLAN SVPKTATSIL QLVGALVLML IMDWRMTIIM FIAVPLVLIC 
181:	LLPIVRQSHK VARARQDALA DLNGKAGEML GEVRLVKSST AENLERTAGD KRMYRLYRIG 
241:	LKEAIYDSIA GPVMGMVMMA MVLEILGYGA IRVREGAIDI GTLFSFLMYL VQMISPFAVL 
301:	GQFMSDVAKA SGSTTRIQAL LQTHEEDRLT GTDLDIGDQT LQMNHVSFSY DQHHPILSGV 
361:	SFTAEPNSVI AFAGPSGGGK STISSLIERF YEPNEGSITI GNTNITDIQL ADWRQQIGLV 
421:	GQDAAIMSGT IRYNLTYGLP GHFSDEQLWH VLEMAYATQF VQKMPRGLDT EVGERGVKVS 
481:	GGQRQRLAIA RAFLRNPKIL MLDEATASLD SESEMMVQKA LDQLMANRTT LVIAHRLSTI 
541:	TNADEIYFIE NGRVTGQGTH QQLVKTTPLY REYVKNQSAT SNG