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3.A.1.120.6
The Uup protein (required for bacterial competitiveness (Murat et al., 2008); 39% identical to 3.A.1.120.5).

Accession Number:P43672
Protein Name:ABC transporter ATP-binding protein uup
Length:635
Molecular Weight:72067.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: P43672
EchoBASE: EB2933
EcoGene: EG13134
eggNOG: COG0488
HEGENOM: HBG758042
DIP: DIP-11099N
RefSeq: AP_001579.1    NP_415469.1   
Entrez Gene ID: 945566   
Pfam: PF00005   
BioCyc: EcoCyc:UUP-MONOMER    ECOL168927:B0949-MONOMER   
KEGG: ecj:JW0932    eco:b0949   

Gene Ontology

GO:0005737 C:cytoplasm
GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity
GO:0003677 F:DNA binding
GO:0005515 F:protein binding
GO:0006810 P:transport

References (5)

[1] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Identification and characterization of ssb and uup mutants with increased frequency of precise excision of transposon Tn10 derivatives: nucleotide sequence of uup in Escherichia coli.”  Reddy M.et.al.   9139905
[5] “Isolation of a novel paraquat-inducible (pqi) gene regulated by the soxRS locus in Escherichia coli.”  Koh Y.-S.et.al.   7751275
Structure:
2LW1     

External Searches:

  • Search: DB with
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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSLISMHGAW LSFSDAPLLD NAELHIEDNE RVCLVGRNGA GKSTLMKILN REQGLDDGRI 
61:	IYEQDLIVAR LQQDPPRNVE GSVYDFVAEG IEEQAEYLKR YHDISRLVMN DPSEKNLNEL 
121:	AKVQEQLDHH NLWQLENRIN EVLAQLGLDP NVALSSLSGG WLRKAALGRA LVSNPRVLLL 
181:	DEPTNHLDIE TIDWLEGFLK TFNGTIIFIS HDRSFIRNMA TRIVDLDRGK LVTYPGNYDQ 
241:	YLLEKEEALR VEELQNAEFD RKLAQEEVWI RQGIKARRTR NEGRVRALKA MRRERGERRE 
301:	VMGTAKMQVE EASRSGKIVF EMEDVCYQVN GKQLVKDFSA QVLRGDKIAL IGPNGCGKTT 
361:	LLKLMLGQLQ ADSGRIHVGT KLEVAYFDQH RAELDPDKTV MDNLAEGKQE VMVNGKPRHV 
421:	LGYLQDFLFH PKRAMTPVRA LSGGERNRLL LARLFLKPSN LLILDEPTND LDVETLELLE 
481:	ELIDSYQGTV LLVSHDRQFV DNTVTECWIF EGGGKIGRYV GGYHDARGQQ EQYVALKQPA 
541:	VKKTEEAAAA KAETVKRSSS KLSYKLQREL EQLPQLLEDL EAKLEALQTQ VADASFFSQP 
601:	HEQTQKVLAD MAAAEQELEQ AFERWEYLEA LKNGG