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3.A.1.121.1
Erythromycin ATPase (membrane constituent unknown)

Accession Number:P23212
Protein Name:MsrA
Length:488
Molecular Weight:55912.00
Species:Staphylococcus epidermidis [1282]
Location1 / Topology2 / Orientation3: Cell membrane1 / Peripheral membrane protein2
Substrate erythromycin

Cross database links:

Pfam: PF00005   

Gene Ontology

GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity
GO:0004871 F:signal transducer activity
GO:0046677 P:response to antibiotic
GO:0007165 P:signal transduction

References (1)

[1] “Inducible erythromycin resistance in staphylococci is encoded by a member of the ATP-binding transport super-gene family.”  Ross J.I.et.al.   2233255

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEQYTIKFNQ INHKLTDLRS LNIDHLYAYQ FEKIALIGGN GTGKTTLLNM IAQKTKPESG 
61:	TVETNGEIQY FEQLNMDVEN DFNTLDGSLM SELHIPMHTT DSMSGGEKAK YKLANVISNY 
121:	SPILLLDEPT NHLDKIGKDY LNNILKYYYG TLIIVSHDRA LIDQIADTIW DIQEDGTIRV 
181:	FKGNYTQYQN QYEQEQLEQQ RKYEQYISEK QRLSQASKAK RNQAQQMAQA SSKQKNKSIA 
241:	PDRLSASKEK GTVEKAAQKQ AKHIEKRMEH LEEVEKPQSY HEFNFPQNKI YDIHNNYPII 
301:	AQNLTLVKGS QKLLTQVRFQ IPYGKNIALV GANGVGKTTL LEAIYHQIEG IDCSPKVQMA 
361:	YYRQLAYEDM RDVSLLQYLM DETDSSESFS RAILNNLGLN EALERSCNVL SGGERTKLSL 
421:	AVLFSTKANM LILDEPTNFL DIKTLEALEM FMNKYPGIIL FTSHDTRFVK HVSDKKWELT 
481:	GQSIHDIT