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3.A.1.121.6
MsrD of 487 aas and 0 TMSs. Involved in macrolide resistance (Zhang et al. 2016). Two ATPase domains are present in tandem. The membrane constituent is not known. However, Iannelli et al. 2018 suggested that MefA (TC# 2.a.1.21.1) can function with MsrD, and therefore that this MFS exporter can function as an ABC drug exporter.  However, the data presented seem inconsistent with this suggestion. The two genes encoding these two proteins are adjacent to each other, suggesting that they may somehow function together (Iannelli et al. 2018).

Accession Number:Q65AB2
Protein Name:ABC-transporter
Length:487
Molecular Weight:54804.00
Species:Streptococcus pyogenes [1314]
Number of TMSs:2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MELILKAKDI RVEFKGHDVL DINELEVYDY DRIGLVGANG AGKSTLFKVL LGELIPPGCK 
61:	MNHLGELAYI PQLDEVTLQE EKDFALVGKL GVEQLNIQTM SGGEETRLKI AQALSAQVHG 
121:	ILADEPTSHL DREGIDFLIG QLKYFTGALL VISHDRYFLD EIVDKIWELK DGKITEYWGN 
181:	YSDYLRQKEE ERKRQAAEYE QFIAERARLE RAAEEKRKQA RKIEQKAKGS SKKKSTEGGG 
241:	RLAHQKSIGS KEKKMHNAAK SLENRIAALG KVEAPEGIRR IRFRQSKALE LHNPYPIVGA 
301:	EINKVFGDKA LFENASFQIP LGAKVALTGG NGTGKTTLIQ MILNHEEGIS ISPKAKIGYF 
361:	AQNGYKYNSN QNVMEFMQKD CDYNISEIRS VLASMGFKQN DIGKSLSVLS GGEIIKLLLA 
421:	KMLMGRYNIL IMDEPSNFLD IPSLEALEIL MKEYTGTIVF ITHDKRLLEN VADVVYEIRD 
481:	KKIKLKH